Misoprostol interactions

Full monograph for Misoprostol Check it against another medicine

Medicines

318 documented

Severity

Mechanism

Medicines documented to interact with Misoprostol, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Oxytocin	Major	Synergy	Prostaglandins, especially those of the E type such as misoprostol, may potentiate the uterine response to oxytocin and increase the risk of uterine…	4 sources — open the full entry
Aluminium Hydroxide + Magnesium Hydroxide	Moderate	Absorption · Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…2 documented mechanisms	4 sources — open the full entry
Aluminium Hydroxide + Magnesium Hydroxide + Simethicone	Moderate	Absorption · Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…2 documented mechanisms	4 sources — open the full entry
Aluminium Oxide + Magnesium Trisilicate	Moderate	Absorption · Synergy	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Calcium acetate + Magnesium carbonate	Moderate	Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Magaldrate	Moderate	Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Magaldrate + Simethicone	Moderate	Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Magnesium Hydroxide	Moderate	Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Magnesium Hydroxide + Liquid Paraffin	Moderate	Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Magnesium Oxide	Moderate	Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Sodium Picosulfate + Magnesium Oxide + Citric Acid	Moderate	Others	Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid…	2 sources — open the full entry
Calcium Carbonate	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C + Vitamin D3	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry
Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 + Multiminerals	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry
Naproxen Sodium	Minor	Synergy	single case report suggests that concomitant use of naproxen and misoprostol may increase the risk of neurological side effects. Until more data are available…	1 sources — open the full entry
Naproxen Sodium + Esomeprazole Magnesium	Minor	Synergy	single case report suggests that concomitant use of naproxen and misoprostol may increase the risk of neurological side effects. Until more data are available…	1 sources — open the full entry
Sodium Alginate + Sodium Bicarbonate + Calcium Carbonate	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…2 documented mechanisms	2 sources — open the full entry
Sodium Bicarbonate	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry
Sodium Bicarbonate + Citric Acid + Sodium Carbonate	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry
Sodium Bicarbonate [Ear Preparations]	Minor	Absorption	Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction…	2 sources — open the full entry

Conditions

Conditions in which Misoprostol needs care, as documented in this source.

Cardiovascular Diseases
Moderate
Caution should be employed when administering misoprostol to patients with preexisting cardiovascular disease.
1 source
1. "Product Information. Cytotec (misoprostol)." Searle (2001):
Diarrhea
Moderate
Diarrhea may occur in up to 40% of patients receiving misoprostol. Misoprostol should be administered cautiously in patients with underlying conditions such as inflammatory bowel disease and dehydration. Careful monitoring during therapy is recommended.
2 sources
1. Wildeman RA "Focus on misoprostol: review of worldwide safety data." Clin Invest Med 10 (1987): 243-5
2. "Product Information. Cytotec (misoprostol)." Searle (2001):

Medicines

Conditions

Cardiovascular Diseases

Diarrhea