Aluminium Hydroxide + Magnesium Hydroxide interactions

Food & lifestyle

• citrus fruits

  Major

  Absorption

  The concomitant administration of aluminum-containing products (e.g., antacids and phosphate binders) and citrates may significantly increase serum aluminum concentrations, resulting in toxicity. Citrates or citric acid are contained in numerous soft drinks, citrus fruits, juices, and effervescent and dispersible drug formulations. Citrates enhance the gastrointestinal absorption of aluminum by an unknown mechanism, which may involve the formation of a soluble aluminum-citrate complex.

  What to do: Some experts recommend that antacids should not be mixed with or given after high protein formulations, that the antacid dose should be separated from the feeding by as much as possible, and that the tube should be thoroughly flushed before administration.

  2 sources

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67

• soft drinks

  Major

  Absorption

  The concomitant administration of aluminum-containing products (e.g., antacids and phosphate binders) and citrates may significantly increase serum aluminum concentrations, resulting in toxicity. Citrates or citric acid are contained in numerous soft drinks, citrus fruits, juices, and effervescent and dispersible drug formulations. Citrates enhance the gastrointestinal absorption of aluminum by an unknown mechanism, which may involve the formation of a soluble aluminum-citrate complex.

  What to do: Some experts recommend that antacids should not be mixed with or given after high protein formulations, that the antacid dose should be separated from the feeding by as much as possible, and that the tube should be thoroughly flushed before administration.

  2 sources

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67

Conditions

Conditions in which Aluminium Hydroxide + Magnesium Hydroxide needs care, as documented in this source.

• Constipation

  Major

  Aluminum containing antacids may produce constipation, which may lead to intestinal obstruction. Osteomalacia and hypophosphatemia may be produced in patients with renal dysfunction who are not receiving dialysis. Patients with renal dysfunction, intestinal obstruction, osteomalacia, or hypophosphatemia should use antacids with low or no aluminum content.

  3 sources

  1. "Product Information. Amphojel (aluminum hydroxide)." Wyeth-Ayerst Laboratories (2001):
  2. "Product Information. Rolaids (dihydroxyaluminum sodium carbonate)." Warner Lambert Consumer Healthcare (2001):
  3. "Product Information. Losospan (magaldrate)." Whitehall-Robbins (2001):

• Inflammatory Bowel Diseases

  Major

  The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

  6 sources

  1. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc (2001):
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb
  4. "Product Information. Neoloid (castor oil)." Paddock Laboratories Inc (2001):
  5. "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
  6. "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):

• Intestinal Obstruction

  Major

  The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

  8 sources

  1. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc (2001):
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb
  4. "Product Information. Fleet Mineral Oil Enema (mineral oil)." Fleet (2001):
  5. "Product Information. Citrucel (methylcellulose)." SmithKline Beecham (2001):
  6. "Product Information. Fleet Babylax (glycerin)." Alcon Laboratories Inc (2001):
  7. "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
  8. "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):

• Kidney Diseases

  Major

  Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.

  5 sources

  1. "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine Company Inc. (2001):
  2. "Product Information. Uro-Mag (magnesium oxide)." Blaine Company Inc. (2001):
  3. "Product Information. Slow-Mag (magnesium chloride)." Searle (2001):
  4. "Product Information. Magonate (magnesium gluconate)." Fleming and Company (2001):
  5. "Product Information. Losospan (magaldrate)." Whitehall-Robbins (2001):

Therapeutic duplication

Drug classes that overlap with Aluminium Hydroxide + Magnesium Hydroxide, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.

• stimulant and hyperosmotic laxat

  The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.

  Example product in the source data (US market): Urolet mb

• stimulant and hyperosmotic laxat

  The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.

  Example product in the source data (US market): Phosphasal

• stimulant and hyperosmotic laxat

  The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.

  Example product in the source data (US market): Suprep bowel prep kit

• stimulant and hyperosmotic laxat

  The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.

  Example product in the source data (US market): Sutab

• stimulant and hyperosmotic laxat

  The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.

  Example product in the source data (US market): Prepopik

• stimulant and hyperosmotic laxat

  The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.

  Example product in the source data (US market): Mannitol/sorbitol (topical)