Linaclotide interactions

Full monograph for Linaclotide Check it against another medicine

Medicines

70 documented

Severity

Mechanism

Medicines documented to interact with Linaclotide, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Cyproterone Acetate + Ethinyl Estradiol	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Desogestrel	Moderate	Absorption	The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been associated with…	3 sources — open the full entry
Dienogest	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…2 documented mechanisms	42 sources — open the full entry
Dienogest + Estradiol Valerate	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…2 documented mechanisms	42 sources — open the full entry
Drospirenone + Ethinyl Estradiol0.02 mg 0.03 mg	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Drospirenone + Ethinyl Estradiol + Levomefolate	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Ethinyl Estradiol + Desogestrel0.02 mg 0.03 mg	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…2 documented mechanisms	42 sources — open the full entry
Ethinyl Estradiol + Gestodene	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Ethinyl Estradiol + Levonorgestrel + Ferrous Fumarate	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…2 documented mechanisms	39 sources — open the full entry
Ethinyl Estradiol + Lynestrenol0.0375 mg 0.05 mg	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Levonorgestrel [For emergency contraception]	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Levothyroxine Sodium	Moderate	Absorption	The efficacy of drugs with a narrow therapeutic index, such as levothyroxine, that are absorbed in the intestinal tract may be reduced if severe diarrhea…	7 sources — open the full entry
Norethisterone Acetate	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Norgestrel + Ethinyl Estradiol + Ferrous Fumarate	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…2 documented mechanisms	39 sources — open the full entry
Norgestrel [For breastfeeding mother]	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Relugolix + Estradiol + Norethindrone	Moderate	Absorption	RECOMMENDED: The absorption and efficacy of oral contraceptives may be reduced if severe diarrhea occurs with linaclotide treatment. Linaclotide has been…	39 sources — open the full entry
Aluminium Hydroxide + Magnesium Hydroxide	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Aluminium Hydroxide + Magnesium Hydroxide + Simethicone	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Bisacodyl	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Bromfenac Sodium	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Calamine + Zinc Oxide + Glycerine	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Carboxymethylcellulose Sodium + Glycerin	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Dexibuprofen	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Dexketoprofen	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Dexlansoprazole	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Diclofenac Diethylamine + Mephenesin + Menthol + Methyl Salicylate + Turpentine Oil	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Diclofenac Potassium	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Diclofenac Sodium	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Diclofenac Sodium + Lidocaine Hydrochloride	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Diclofenac Sodium + Methyl Salicylate + Linseed Oil + Menthol	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Diclofenac Sodium + Misoprostol	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Docusate SodiumEar drop Oral	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Esomeprazolebase MUPS preparation	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Esomeprazole + Amoxicillin + Clarithromycin	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Ethyl Alcohol + Hydrogen peroxide + Glycerol	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Etodolac	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Flurbiprofen	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Glycerin	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Glycerin + Hypromellose + Polyethylene glycol + Tetrahydrozoline + Zinc Sulfate	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Glycerol	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Glycerol + Hypromellose + Polyethylene Glycol 400	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Glycerol + Liquid Sugar	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Hydroxyethyl Cellulose + Glycerin	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
IbuprofenOral Topical	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Ibuprofen + Paracetamol	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
IndomethacinOral Rectal	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Isopropyl Alcohol + Hydrogen Peroxide + Glycerol	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Ketoprofenbase Topical	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Ketorolac Tromethamine	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry
Lactulose	Minor	Others	The concomitant use of linaclotide with proton pump inhibitors, laxatives, or nonsteroidal anti-inflammatory drugs may increase the risk of diarrhea.	3 sources — open the full entry

Food & lifestyle

food
Moderate
Synergy
Administration of linaclotide in the fed condition resulted in more gastrointestinal side effects and more frequent and looser stools, than when it was administered under fasting conditions.
What to do: It is recommended to take linaclotide 30 minutes before a meal.
2 sources
1. EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid" (2007):
2. "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals (2012):

Conditions

Conditions in which Linaclotide needs care, as documented in this source.

Intestinal Obstruction
Major
The use of linaclotide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Because linaclotide accelerates gastrointestinal transit, it can exacerbate a blockage.
1 source
1. "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals (2012):
Diarrhea
Moderate
The use of linaclotide may cause diarrhea that might be associated with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia and hyponatremia). It is recommended to withhold dosing and rehydrate patients if severe diarrhea occurs. Care should be exercised when prescribing this agent to patients at risk of diarrhea or dehydration.
1 source
1. "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals (2012):

Medicines

Food & lifestyle

food

Conditions

Intestinal Obstruction

Diarrhea