Desogestrel interactions
Full monograph for DesogestrelCheck it against another medicine
Medicines
143 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Bosentan Monohydrate | Major | Metabolism | Coadministration with bosentan may decrease the plasma concentrations and efficacy of contraceptive hormones. The mechanism is bosentan induction of CYP450… | 2 sources — open the full entry |
| Brigatinib | Major | Metabolism | Coadministration with brigatinib may decrease the plasma concentrations of contraceptive hormones. Brigatinib has been shown in vitro to induce CYP450 3A4 at… | 1 sources — open the full entry |
| Carbamazepine | Major | Antagonism | Coadministration with certain anticonvulsants such as carbamazepine, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, and primidone may reduce the… | 33 sources — open the full entry |
| Carfilzomib | Major | Synergy | Venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), have occurred during treatment with carfilzomib, and concurrent… | 2 sources — open the full entry |
| Fosphenytoin Sodium | Major | Antagonism | Coadministration with certain anticonvulsants such as carbamazepine, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, and primidone may reduce the… | 33 sources — open the full entry |
| Griseofulvin [Ultra Microsize] | Major | Metabolism | Limited clinical data suggest that griseofulvin may reduce the efficacy of contraceptive hormones.The proposed mechanism is accelerated clearance of the… | 13 sources — open the full entry |
| Mavacamten | Major | Metabolism | Coadministration with mavacamten may decrease the plasma concentrations and efficacy of contraceptive hormones. The proposed mechanism is mavacamten induction… | 1 sources — open the full entry |
| Mycophenolate Mofetil | Major | Others | Coadministration with mycophenolic acid may decrease the plasma concentrations and, theoretically, the efficacy of contraceptive hormones. The mechanism of…2 documented mechanisms | 39 sources — open the full entry |
| Mycophenolic acid | Major | Others | Coadministration with mycophenolic acid may decrease the plasma concentrations and, theoretically, the efficacy of contraceptive hormones. The mechanism of… | 2 sources — open the full entry |
| Oxcarbazepine | Major | Antagonism · Metabolism | Coadministration with certain anticonvulsants such as carbamazepine, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, and primidone may reduce the…2 documented mechanisms | 98 sources — open the full entry |
| Phenobarbital | Major | Antagonism | Coadministration with certain anticonvulsants such as carbamazepine, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, and primidone may reduce the… | 33 sources — open the full entry |
| Phenytoin Sodium | Major | Antagonism | Coadministration with certain anticonvulsants such as carbamazepine, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, and primidone may reduce the… | 33 sources — open the full entry |
| Primidone | Major | Antagonism | Coadministration with certain anticonvulsants such as carbamazepine, eslicarbazepine, oxcarbazepine, phenobarbital, phenytoin, and primidone may reduce the… | 33 sources — open the full entry |
| Rifampicin | Major | Metabolism | Coadministration with rifampin or other rifamycins may reduce the efficacy of contraceptive hormones.The interaction stems from accelerated clearance of… | 32 sources — open the full entry |
| Rifampicin + Isoniazid | Major | Metabolism | Coadministration with rifampin or other rifamycins may reduce the efficacy of contraceptive hormones.The interaction stems from accelerated clearance of… | 32 sources — open the full entry |
| Rifampicin + Isoniazid + Pyrazinamide + Ethambutol | Major | Metabolism | Coadministration with rifampin or other rifamycins may reduce the efficacy of contraceptive hormones.The interaction stems from accelerated clearance of… | 32 sources — open the full entry |
| Tizanidine Hydrochloride | Major | Metabolism | Coadministration with oral contraceptives may significantly increase the plasma concentrations and pharmacologic effects of tizanidine. The proposed mechanism…2 documented mechanisms | 48 sources — open the full entry |
| Topiramate | Major | Metabolism | Coadministration with topiramate, particularly at dosages above 200 mg/day, may decrease the plasma concentrations and efficacy of contraceptive hormones. The… | 18 sources — open the full entry |
| Tranexamic Acid | Major | Synergy | Because tranexamic acid is an antifibrinolytic agent, concomitant use may further exacerbate the risk of thrombotic events, including venous thromboembolism as… | 6 sources — open the full entry |
| Abametapir | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Acarbose | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 85 sources — open the full entry |
| Adalimumab | Moderate | Metabolism | Plasma concentrations of drugs that are CYP450 substrates may decrease following the initiation of interleukin (IL) inhibitors, tumor necrosis factor (TNF)…2 documented mechanisms | 34 sources — open the full entry |
| Alogliptin Benzoate | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 180 sources — open the full entry |
| Aminophylline | Moderate | Metabolism | The coadministration with contraceptive steroids may increase the plasma concentrations of theophylline and other methylxanthines. The proposed mechanism is… | 3 sources — open the full entry |
| Apalutamide | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of estrogens and progestins. Estrogens have been shown in in vitro and in… | 47 sources — open the full entry |
| Aprepitant | Moderate | Metabolism | Aprepitant and its prodrug, fosaprepitant, may reduce the efficacy of low-dose hormonal contraceptives during and for up to 28 days after treatment. The…2 documented mechanisms | 38 sources — open the full entry |
| Armodafinil | Moderate | Metabolism | Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations of ethinyl estradiol and other… | 6 sources — open the full entry |
| Asciminib | Moderate | Metabolism | Coadministration with asciminib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is… | 1 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocaine | Moderate | Metabolism | Azole antifungal agents may increase the plasma concentrations of estrogens and progestins. The mechanism is decreased clearance of the hormones due to… | 6 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Metabolism | Azole antifungal agents may increase the plasma concentrations of estrogens and progestins. The mechanism is decreased clearance of the hormones due to… | 6 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Metabolism | Azole antifungal agents may increase the plasma concentrations of estrogens and progestins. The mechanism is decreased clearance of the hormones due to… | 6 sources — open the full entry |
| Biphasic Insulin Aspart | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 180 sources — open the full entry |
| Canagliflozin Hemihydrate | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 85 sources — open the full entry |
| Cenobamate | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of estrogens and progestins. Estrogens have been shown in in vitro and in… | 47 sources — open the full entry |
| Clarithromycin | Moderate | Others | The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. | 7 sources — open the full entry |
| Clobazam | Moderate | Metabolism | Coadministration with clobazam, a weak inducer of CYP450 3A4, may decrease the plasma concentrations of contraceptive hormones.2 documented mechanisms | 42 sources — open the full entry |
| ClotrimazoleEar dropEye ointmentTopicalVaginal tablet | Moderate | Metabolism | Azole antifungal agents may increase the plasma concentrations of estrogens and progestins. The mechanism is decreased clearance of the hormones due to… | 6 sources — open the full entry |
| Clotrimazole + Hydrocortisone | Moderate | Metabolism | Azole antifungal agents may increase the plasma concentrations of estrogens and progestins. The mechanism is decreased clearance of the hormones due to… | 6 sources — open the full entry |
| Clozapine | Moderate | Metabolism | Limited data suggest that coadministration with contraceptive hormones may increase the plasma concentrations of clozapine. The exact mechanism of interaction… | 1 sources — open the full entry |
| Cyclosporine (Oral) | Moderate | Metabolism | Coadministration with some estrogens or progestins may increase the plasma concentrations of cyclosporine. The risk of cyclosporine-induced nephrotoxicity… | 2 sources — open the full entry |
| Dapagliflozin Propanediol | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…2 documented mechanisms | 180 sources — open the full entry |
| Deferasirox | Moderate | Metabolism | Coadministration with deferasirox may decrease the plasma concentrations of contraceptive hormones. The proposed mechanism is deferasirox induction of CYP450…2 documented mechanisms | 38 sources — open the full entry |
| Diltiazem Hydrochloride | Moderate | Metabolism | Coadministration with diltiazem may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased… | 5 sources — open the full entry |
| Dulaglutide | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 85 sources — open the full entry |
| Efavirenz | Moderate | Metabolism | There are limited data concerning the potential effect of efavirenz on hormonal contraceptives. Presumably, coadministration with efavirenz may decrease the…2 documented mechanisms | 41 sources — open the full entry |
| Elagolix Sodium | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of estrogens and progestins. Estrogens have been shown in in vitro and in… | 47 sources — open the full entry |
| Empagliflozin | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 85 sources — open the full entry |
| Empagliflozin + Linagliptin | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…3 documented mechanisms | 180 sources — open the full entry |
| Empagliflozin + Metformin Hydrochloride | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics…3 documented mechanisms | 180 sources — open the full entry |
| Enasidenib | Moderate | Metabolism | Coadministration with enasidenib may alter the plasma concentrations of hormonal contraceptives. In vitro, enasidenib has been found to both inhibit and induce… | 1 sources — open the full entry |
This source documents no food, condition or duplication entries for Desogestrel.