Lactulose interactions
Full monograph for LactuloseCheck it against another medicine
Medicines
609 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Abiraterone Acetate | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Acetazolamide | Moderate | Synergy | The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes… | 5 sources — open the full entry |
| Acyclovir + Hydrocortisone | Moderate | Antagonism · Unknown | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 7 sources — open the full entry |
| Alfuzosin Hydrochloride | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Amiodarone Hydrochloride | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Amisulpride | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Apalutamide | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Arsenic Trioxide | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Artemether + Lumefantrine | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in…2 documented mechanisms | 12 sources — open the full entry |
| Asciminib | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Asenapine Maleate | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Atenolol + Chlorthalidone | Moderate | Synergy · Unknown | The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes…2 documented mechanisms | 5 sources — open the full entry |
| Atomoxetine Hydrochloride | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Azilsartan Medoxomil + Chlorthalidone | Moderate | Synergy | The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes… | 5 sources — open the full entry |
| Azithromycin DihydratebaseOphthalmic | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Betamethasone | Moderate | Antagonism | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy… | 7 sources — open the full entry |
| Betamethasone + Calcipotriol | Moderate | Antagonism | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy… | 7 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Antagonism · Unknown | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 7 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Antagonism · Unknown | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…3 documented mechanisms | 7 sources — open the full entry |
| Betamethasone + Neomycin Sulphate (Ophthalmic) | Moderate | Antagonism · Others | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 11 sources — open the full entry |
| Betamethasone + Phenylephrine + Lignocaine | Moderate | Antagonism · Unknown | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 7 sources — open the full entry |
| Betamethasone Dipropionate | Moderate | Antagonism | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy… | 7 sources — open the full entry |
| Betamethasone Dipropionate + Salicylic Acid | Moderate | Antagonism | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy… | 7 sources — open the full entry |
| Betamethasone Sodium Phosphate | Moderate | Antagonism | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy… | 7 sources — open the full entry |
| Betamethasone Valerate | Moderate | Antagonism | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy… | 7 sources — open the full entry |
| Bicalutamide | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Bisacodyl | Moderate | Others | In the treatment of portal-systemic encephalopathy, the loose stools produced by concomitant use of other laxatives may falsely suggest that adequate lactulose… | 5 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazide | Moderate | Synergy · Unknown | The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes…2 documented mechanisms | 5 sources — open the full entry |
| Bumetanide | Moderate | Synergy | The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes… | 5 sources — open the full entry |
| Cabozantinib | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Calamine + Zinc Oxide + Glycerine | Moderate | Others | In the treatment of portal-systemic encephalopathy, the loose stools produced by concomitant use of other laxatives may falsely suggest that adequate lactulose… | 5 sources — open the full entry |
| Calcium Dobesilate + Lidocaine + Dexamethasone | Moderate | Antagonism · Unknown | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 7 sources — open the full entry |
| Candesartan Cilexetil + Hydrochlorothiazide | Moderate | Synergy | The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes… | 5 sources — open the full entry |
| Carboxymethylcellulose Sodium + Glycerin | Moderate | Others | In the treatment of portal-systemic encephalopathy, the loose stools produced by concomitant use of other laxatives may falsely suggest that adequate lactulose… | 5 sources — open the full entry |
| Ceritinib | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Chlorpromazine Hydrochloride | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Chlorthalidone | Moderate | Synergy | The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes… | 5 sources — open the full entry |
| Cilostazol | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Framycetin + Esculin | Moderate | Antagonism · Others | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 11 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Neomycin + Esculin | Moderate | Antagonism · Others | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 11 sources — open the full entry |
| CiprofloxacinbaseOphthalmic | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Antagonism · Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in…2 documented mechanisms | 13 sources — open the full entry |
| Ciprofloxacin + Hydrocortisone Acetate | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Citalopram Hydrobromide | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Clarithromycin | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafine | Moderate | Synergy · Unknown | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in…2 documented mechanisms | 6 sources — open the full entry |
| Clotrimazole + Hydrocortisone | Moderate | Antagonism · Unknown | The overuse or abuse of laxatives can cause significant loss of electrolytes and potentiate the risk of hypokalemia associated with corticosteroid therapy…2 documented mechanisms | 7 sources — open the full entry |
| Clozapine | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Crizotinib | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
| Dasatinib | Moderate | Synergy | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in… | 6 sources — open the full entry |
Conditions
Conditions in which Lactulose needs care, as documented in this source.
Galactosemias
MajorSince lactulose solution contains galactose, use is contraindicated in patients who require a low galactose diet.
4 sources
- "Product Information. Chronulac (lactulose)." Hoechst Marion Roussel (2002):
- "Product Information. Cephulac (lactulose)." Hoechst Marion Roussel (2002):
- "Product Information. Duphalac (lactulose)." Solvay Pharmaceuticals Inc (2001):
- "Product Information. Enulose (lactulose)." United Research Laboratories/Mutual Pharmaceutical Company (2012):
Inflammatory Bowel Diseases
MajorThe use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.
6 sources
- "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc (2001):
- "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet
- "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb
- "Product Information. Neoloid (castor oil)." Paddock Laboratories Inc (2001):
- "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
- "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):
Intestinal Obstruction
MajorThe use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.
8 sources
- "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc (2001):
- "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet
- "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb
- "Product Information. Fleet Mineral Oil Enema (mineral oil)." Fleet (2001):
- "Product Information. Citrucel (methylcellulose)." SmithKline Beecham (2001):
- "Product Information. Fleet Babylax (glycerin)." Alcon Laboratories Inc (2001):
- "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
- "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):
Diabetes Mellitus
ModerateSince lactulose solution contains galactose and lactose, it should be used cautiously in patients with diabetes.
4 sources
- "Product Information. Chronulac (lactulose)." Hoechst Marion Roussel (2002):
- "Product Information. Cephulac (lactulose)." Hoechst Marion Roussel (2002):
- "Product Information. Duphalac (lactulose)." Solvay Pharmaceuticals Inc (2001):
- "Product Information. Enulose (lactulose)." United Research Laboratories/Mutual Pharmaceutical Company (2012):
Therapeutic duplication
Drug classes that overlap with Lactulose, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Peri-colace
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Rolaids regular strength
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Pepcid complete
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Mylanta tonight
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Suprep bowel prep kit
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Sutab
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Prepopik
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Rulox
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): First mouthwash blm
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Fleet phospho soda
stimulant and hyperosmotic laxat
The recommended maximum number of medicines in the 'stimulant and hyperosmotic laxatives' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'stimulant and hyperosmotic laxatives' category.
Example product in the source data (US market): Mannitol/sorbitol (topical)