Vericiguat interactions

Full monograph for Vericiguat Check it against another medicine

Medicines

91 documented

Severity

Medicines documented to interact with Vericiguat, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Avanafil	Major	Synergy	Coadministration of vericiguat and phosphodiesterase type 5 (PDE-5) inhibitors may result in additive hypotension. PDE-5 inhibitors prevent degradation of…	10 sources — open the full entry
Finasteride + Tadalafil	Major	Synergy	Coadministration of vericiguat and phosphodiesterase type 5 (PDE-5) inhibitors may result in additive hypotension. PDE-5 inhibitors prevent degradation of…	10 sources — open the full entry
Sildenafil Citrate	Major	Synergy	Coadministration of vericiguat and phosphodiesterase type 5 (PDE-5) inhibitors may result in additive hypotension. PDE-5 inhibitors prevent degradation of…	10 sources — open the full entry
Tadalafil	Major	Synergy	Coadministration of vericiguat and phosphodiesterase type 5 (PDE-5) inhibitors may result in additive hypotension. PDE-5 inhibitors prevent degradation of…	10 sources — open the full entry
Vardenafil	Major	Synergy	Coadministration of vericiguat and phosphodiesterase type 5 (PDE-5) inhibitors may result in additive hypotension. PDE-5 inhibitors prevent degradation of…	10 sources — open the full entry
Acetazolamide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Alfuzosin Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Amlodipine Besilate	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Amlodipine Besilate + Atenolol	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Amlodipine Besilate + Atorvastatin	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Amlodipine Besilate + Benazepril Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Amlodipine Besilate + Olmesartan Medoxomil	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Amlodipine Besilate + Telmisartan	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Amlodipine Besilate + Valsartan	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Atenolol	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Atenolol + Chlorthalidone	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Azilsartan Medoxomil	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Azilsartan Medoxomil + Chlorthalidone	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Betaxolol Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Bimatoprost + Timolol	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Bisoprolol Fumarate	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Bisoprolol Fumarate + Amlodipine Besilate	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Bisoprolol Fumarate + Hydrochlorothiazide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Brimonidine Tartrate + Timolol Maleate	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Brinzolamide + Timolol	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Bumetanide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Candesartan Cilexetil	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Candesartan Cilexetil + Hydrochlorothiazide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Captopril	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Carvedilol	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Chlorthalidone	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Clonidine Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Diazoxide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Diltiazem Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Dorzolamide + Timolol	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Enalapril Maleate	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Eplerenone	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Esmolol Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Finerenone	Moderate	Synergy	Concomitant use of multiple other antihypertensive agents or drugs with hypotensive properties may potentiate the risk of hypotension during treatment with…	1 sources — open the full entry
Furosemide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Furosemide + Spironolactone	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Hydrochlorothiazide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Indapamide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Indapamide + Amlodipine	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Irbesartan	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Irbesartan + Hydrochlorothiazide	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Isosorbide Dinitrate + Hydralazine Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…2 documented mechanisms	2 sources — open the full entry
Isosorbide Mononitrate	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Labetalol Hydrochloride	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry
Latanoprost + Timolol	Moderate	Synergy	Vericiguat may cause hypotension and coadministration with antihypertensives or organic nitrates may increase the potential for symptomatic hypotension…	2 sources — open the full entry

Food & lifestyle

high-fat foods
Moderate
Absorption
Administration of vericiguat with food reduces its pharmacokinetic variability and increases its exposure. Vericiguat is less soluble at neutral pH than at acidic pH. Administration of vericiguat with a high-fat, high-calorie meal or low-fat, high-carbohydrate meal increased time to reach peak plasma concentration (Tmax) from about 1 hour (fasted) to about 4 hours (fed) and increased vericiguat systemic exposure (AUC) by 19% and peak plasma concentration (Cmax) by 9% for the 5 mg tablet and by 44% (AUC) and 41% (Cmax) for the 10 mg tablet as compared with the fasted state. Concurrent treatment with drugs that increase gastric pH, such as proton pump inhibitors or antacids, decrease vericiguat AUC by about 30%. Co-treatment with drugs that increase gastric pH did not affect vericiguat exposure in patients with heart failure when vericiguat was taken as directed with food.
What to do: Administer vericiguat with food to ensure maximal exposure and decrease pharmacokinetic variability.
2 sources
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Verquvo (vericiguat)." Merck & Co., Inc (2021):

Conditions

Conditions in which Vericiguat needs care, as documented in this source.

Hepatic Insufficiency
Moderate
Vericiguat has not been studied in patients with severe hepatic impairment (Child-Pugh C). Caution is advised. No dosage adjustment is recommended in patients with mild or moderate hepatic impairment (Child-Pugh A or B).
1 source
1. "Product Information. Verquvo (vericiguat)." Merck & Co., Inc (2021):
Kidney Diseases
Moderate
Vericiguat has not been studied in patients with eGFR <15 mL/min/1.73m2 or on dialysis. Caution is advised. No dose adjustment is required for patients with eGFR >15 mL/min/1.73m2 not on dialysis.
1 source
1. "Product Information. Verquvo (vericiguat)." Merck & Co., Inc (2021):

Medicines

Food & lifestyle

high-fat foods

Conditions

Hepatic Insufficiency

Kidney Diseases