Tadalafil interactions
Full monograph for TadalafilCheck it against another medicine
Medicines
401 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Avanafil | Major | Synergy | The safety and efficacy of combining a phosphodiesterase-5 (PDE5) inhibitor with other PDE-5 inhibitors or other treatments for erectile dysfunction have not… | 9 sources — open the full entry |
| Isosorbide Dinitrate + Hydralazine Hydrochloride | Major | Synergy | Phosphodiesterase-5 (PDE5) inhibitors may potentiate the hypotensive effect of organic nitrates. Severe hypotension, syncope, or myocardial ischemia may result…2 documented mechanisms | 9 sources — open the full entry |
| Isosorbide Mononitrate | Major | Synergy | Phosphodiesterase-5 (PDE5) inhibitors may potentiate the hypotensive effect of organic nitrates. Severe hypotension, syncope, or myocardial ischemia may result… | 5 sources — open the full entry |
| NitroglycerinbaseIV InfusionOintment | Major | Synergy | Phosphodiesterase-5 (PDE5) inhibitors may potentiate the hypotensive effect of organic nitrates. Severe hypotension, syncope, or myocardial ischemia may result… | 5 sources — open the full entry |
| Vericiguat | Major | Synergy | Coadministration of vericiguat and phosphodiesterase type 5 (PDE-5) inhibitors may result in additive hypotension. PDE-5 inhibitors prevent degradation of… | 10 sources — open the full entry |
| Abametapir | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Alfuzosin Hydrochloride | Moderate | Synergy | Tadalafil may potentiate the hypotensive effect of alpha blockers, resulting in symptomatic hypotension in some patients. Tadalafil inhibits… | 6 sources — open the full entry |
| Amiodarone Hydrochloride | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Apalutamide | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Aprepitant | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Asciminib | Moderate | Metabolism | Coadministration with asciminib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is… | 1 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocaine | Moderate | Metabolism · Unknown | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The…2 documented mechanisms | 3 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Bicalutamide | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Bosentan Monohydrate | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Brigatinib | Moderate | Metabolism | Coadministration with brigatinib may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. Brigatinib has been shown in… | 6 sources — open the full entry |
| Calcium Dobesilate + Lidocaine + Dexamethasone | Moderate | Metabolism · Unknown | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme.2 documented mechanisms | 5 sources — open the full entry |
| Canagliflozin Hemihydrate | Moderate | Synergy | Sodium-glucose co-transporter 2 (SGLT-2) inhibitors may potentiate the hypotensive effects of diuretics and other antihypertensive agents or vasodilators… | 15 sources — open the full entry |
| Carbamazepine | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Cenobamate | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Ceritinib | Moderate | Metabolism | Coadministration with drugs that are potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of tadalafil, which is primarily… | 8 sources — open the full entry |
| CiprofloxacinbaseOphthalmic | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The…2 documented mechanisms | 8 sources — open the full entry |
| Ciprofloxacin + Hydrocortisone Acetate | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Clarithromycin | Moderate | Metabolism | Coadministration with drugs that are potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of tadalafil, which is primarily… | 8 sources — open the full entry |
| ClotrimazoleEar dropEye ointmentTopicalVaginal tablet | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Clotrimazole + Hydrocortisone | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Copper Peptide + Procapil + Niacinamide + Biotin + L-Arginine | Moderate | Synergy | Coadministration of L-arginine or L-citrulline may potentiate the hypotensive effects of nitrates and vasodilators. Both L-arginine and L-citrulline are amino… | 1 sources — open the full entry |
| Crizotinib | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Cyclosporine (Oral) | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Danazol | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Dapagliflozin Propanediol | Moderate | Synergy | Sodium-glucose co-transporter 2 (SGLT-2) inhibitors may potentiate the hypotensive effects of diuretics and other antihypertensive agents or vasodilators… | 15 sources — open the full entry |
| Dasatinib | Moderate | Metabolism | Coadministration with dasatinib may increase the plasma concentrations of drugs that are substrates of CYP450 3A4. The mechanism is decreased clearance due to… | 8 sources — open the full entry |
| Deferasirox | Moderate | Metabolism | Coadministration with deferasirox may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism may involve… | 3 sources — open the full entry |
| Dexamethasone | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Dexamethasone + Chloramphenicol | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Dexamethasone + Levofloxacin | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Dexamethasone + Neomycin + Glacial Acetic Acid | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Dexamethasone + Neomycin Sulphate + Polymyxin B Sulphate | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Dexamethasone + Tobramycin | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Diltiazem Hydrochloride | Moderate | Metabolism | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. The… | 3 sources — open the full entry |
| Efavirenz | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Elagolix Sodium | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Empagliflozin | Moderate | Synergy | Sodium-glucose co-transporter 2 (SGLT-2) inhibitors may potentiate the hypotensive effects of diuretics and other antihypertensive agents or vasodilators… | 15 sources — open the full entry |
| Empagliflozin + Linagliptin | Moderate | Synergy | Sodium-glucose co-transporter 2 (SGLT-2) inhibitors may potentiate the hypotensive effects of diuretics and other antihypertensive agents or vasodilators… | 15 sources — open the full entry |
| Empagliflozin + Metformin Hydrochloride | Moderate | Synergy · Unknown | Sodium-glucose co-transporter 2 (SGLT-2) inhibitors may potentiate the hypotensive effects of diuretics and other antihypertensive agents or vasodilators…2 documented mechanisms | 15 sources — open the full entry |
| Enzalutamide | Moderate | Metabolism | Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of tadalafil, which is primarily metabolized by the isoenzyme. | 5 sources — open the full entry |
| Erdafitinib | Moderate | Metabolism | Coadministration with erdafitinib may alter the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme, resulting in increased toxicity… | 33 sources — open the full entry |
| Ertugliflozin | Moderate | Synergy | Sodium-glucose co-transporter 2 (SGLT-2) inhibitors may potentiate the hypotensive effects of diuretics and other antihypertensive agents or vasodilators… | 15 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Additive hypotensive effects may occur when phosphodiesterase-5 (PDE5) inhibitors such as tadalafil are used with alcohol, as both are mild systemic vasodilators.
What to do: Patients taking tadalafil should avoid consuming large amounts of alcohol, which may increase the potential for orthostatic signs and symptoms including increase in heart rate, decrease in standing blood pressure, dizziness, and headache. It may also be appropriate to avoid consuming large amounts of grapefruit juice.
2 sources
- "Product Information. Cialis (tadalafil)." Lilly, Eli and Company (2003):
- "Product Information. Adcirca (tadalafil)." United Therapeutics Corporation (2009):