Iron Polymaltose Complex + Folic Acid + Zinc Sulfate interactions
Checked as Iron (polysaccharide) + Folic acid + Zinc sulfate in this data source.
Full monograph for Iron Polymaltose Complex + Folic Acid + Zinc SulfateCheck it against another medicine
Medicines
602 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Capecitabinevia Folic acid | Major | Synergy | Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although… | 9 sources — open the full entry |
| Fluorouracilvia Folic acid | Major | Synergy | Coadministration with folate therapy may potentiate the pharmacologic effects of 5-fluorouracil (5-FU). The exact mechanism of interaction is unknown. Although… | 9 sources — open the full entry |
| Alendronic acidvia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms | 15 sources — open the full entry |
| Alendronic Acid + Vitamin D3via Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms | 15 sources — open the full entry |
| Aluminium Hydroxide + Magnesium Hydroxidevia Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…2 documented mechanisms | 12 sources — open the full entry |
| Aluminium Hydroxide + Magnesium Hydroxide + Simethiconevia Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The…2 documented mechanisms | 12 sources — open the full entry |
| Aluminium Oxide + Magnesium Trisilicatevia Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The… | 12 sources — open the full entry |
| Baloxavir Marboxilvia Iron (polysaccharide), Zinc sulfate | Moderate | Absorption | Coadministration with polyvalent cation-containing products may decrease the plasma concentrations and therapeutic efficacy of baloxavir. The proposed…2 documented mechanisms | 4 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocainevia Iron (polysaccharide), Folic acid | Moderate | Metabolism · Unknown | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…4 documented mechanisms | 3 sources — open the full entry |
| Beta carotene + Vitamin C + Vitamin Evia Iron (polysaccharide) | Moderate | Antagonism | Limited data suggest that vitamin E may diminish the therapeutic response to iron therapy in patients with iron deficiency anemia. | 2 sources — open the full entry |
| Calcium acetate + Magnesium carbonatevia Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The… | 12 sources — open the full entry |
| Calcium Carbonatevia Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The… | 12 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin Cvia Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The… | 12 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin C + Vitamin D3via Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The… | 12 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3via Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The… | 12 sources — open the full entry |
| Calcium Lactate Gluconate + Calcium Carbonate + Vitamin D3 + Multimineralsvia Iron (polysaccharide) | Moderate | Absorption | The bioavailability of orally administered iron may be reduced by concomitant administration of antacids or other agents with acid-neutralizing effects. The… | 12 sources — open the full entry |
| Carbamazepinevia Folic acid | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Carbidopa + LevodopaExtended releaseProlonged releasevia Iron (polysaccharide) | Moderate | Absorption | The oral bioavailability and pharmacologic effects of levodopa and carbidopa may be decreased during concurrent administration with iron-containing products… | 4 sources — open the full entry |
| Cefdinirvia Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | The oral bioavailability of cefdinir may be significantly decreased by concomitant administration of iron preparations. The proposed mechanism is chelation of…2 documented mechanisms | 2 sources — open the full entry |
| Ceftibuten Dihydratevia Zinc sulfate | Moderate | Absorption | Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or… | 3 sources — open the full entry |
| Cephalexinvia Zinc sulfate, Folic acid | Moderate | Absorption · Unknown | Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or…2 documented mechanisms | 3 sources — open the full entry |
| Cephradinevia Zinc sulfate | Moderate | Absorption | Oral products containing zinc such as mineral supplements and multivitamins may interfere with the gastrointestinal absorption of cephalexin, ceftibuten or… | 3 sources — open the full entry |
| Chloramphenicol (Oral)via Iron (polysaccharide), Folic acid | Moderate | Metabolism · Unknown | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…2 documented mechanisms | 3 sources — open the full entry |
| Chloramphenicol + Lidocaine Hydrochloridevia Iron (polysaccharide), Folic acid | Moderate | Metabolism · Unknown | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…3 documented mechanisms | 3 sources — open the full entry |
| CiprofloxacinbaseOphthalmicvia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…3 documented mechanisms | 64 sources — open the full entry |
| Ciprofloxacin + Dexamethasonevia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Antagonism · Unknown | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…5 documented mechanisms | 68 sources — open the full entry |
| Ciprofloxacin + Hydrocortisone Acetatevia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…3 documented mechanisms | 64 sources — open the full entry |
| Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafinevia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…5 documented mechanisms | 64 sources — open the full entry |
| Deferipronevia Zinc sulfate, Iron (polysaccharide) | Moderate | Absorption · Antagonism | INTERVAL: Deferiprone has the potential to bind polyvalent cations such as aluminum, iron and zinc, which may reduce its effectiveness. However, concurrent use…2 documented mechanisms | 2 sources — open the full entry |
| Delafloxacinvia Iron (polysaccharide), Zinc sulfate | Moderate | Absorption | Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics. Absorption…2 documented mechanisms | 64 sources — open the full entry |
| Dexamethasone + Chloramphenicolvia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Antagonism · Metabolism · Unknown | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…4 documented mechanisms | 7 sources — open the full entry |
| Dexamethasone + Levofloxacinvia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Antagonism · Unknown | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…4 documented mechanisms | 68 sources — open the full entry |
| Dexlansoprazolevia Iron (polysaccharide) | Moderate | Absorption | Inhibitors of the proton pump (PPIs or potassium-competitive acid blockers [PCABs]) may impair the gastrointestinal absorption of nonheme iron, a process that… | 12 sources — open the full entry |
| Doxycycline Hydrochloridevia Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | The bioavailability of oral tetracyclines and iron salts may be significantly decreased during concurrent administration. Therapeutic failure may result. The…2 documented mechanisms | 11 sources — open the full entry |
| Eltrombopag Olaminevia Zinc sulfate, Iron (polysaccharide) | Moderate | Absorption | INTERVAL: Products containing aluminum, calcium, iron, magnesium, zinc and other polyvalent cations such as antacids or mineral supplements can significantly…2 documented mechanisms | 6 sources — open the full entry |
| EsomeprazolebaseMUPS preparationvia Iron (polysaccharide) | Moderate | Absorption | Inhibitors of the proton pump (PPIs or potassium-competitive acid blockers [PCABs]) may impair the gastrointestinal absorption of nonheme iron, a process that… | 12 sources — open the full entry |
| Esomeprazole + Amoxicillin + Clarithromycinvia Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | Inhibitors of the proton pump (PPIs or potassium-competitive acid blockers [PCABs]) may impair the gastrointestinal absorption of nonheme iron, a process that…3 documented mechanisms | 12 sources — open the full entry |
| Ethosuximidevia Folic acid | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Ferric Carboxymaltosevia Iron (polysaccharide) | Moderate | Absorption | Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations. | 5 sources — open the full entry |
| Ferric Derisomaltosevia Iron (polysaccharide) | Moderate | Absorption | Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations. | 5 sources — open the full entry |
| Ferric Pyrophosphate Citratevia Iron (polysaccharide) | Moderate | Absorption | Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations. | 5 sources — open the full entry |
| Fosphenytoin Sodiumvia Folic acid | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
| Gatifloxacinvia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…3 documented mechanisms | 64 sources — open the full entry |
| Gatifloxacin + Dexamethasonevia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Antagonism · Unknown | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…5 documented mechanisms | 68 sources — open the full entry |
| Gemifloxacinvia Zinc sulfate, Iron (polysaccharide) | Moderate | Absorption | INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics…2 documented mechanisms | 64 sources — open the full entry |
| Ibandronic Acidvia Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms | 15 sources — open the full entry |
| Ibandronic Acid + Algae Calcium + Vitamin D3via Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms | 15 sources — open the full entry |
| Ibandronic Acid + Coral Calcium + Vitamin D3via Zinc sulfate, Iron (polysaccharide), Folic acid | Moderate | Absorption · Unknown | INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to…3 documented mechanisms | 15 sources — open the full entry |
| Iron Sucrosevia Iron (polysaccharide) | Moderate | Absorption | Parenteral iron therapy may reduce the absorption of concomitantly administered oral iron preparations. | 5 sources — open the full entry |
| Lamotriginevia Folic acid | Moderate | Antagonism | Anticonvulsants including, but not limited to, carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid have been shown to impair… | 26 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Ethanol may increase folic acid elimination and folic acid absorption is decreased in chronic alcoholics. Excessive alcohol consumption may lead to folate deficiency.
What to do: Monitoring of patient response to folic acid supplementation if they also consume alcohol regularly may be recommended.
5 sources
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia Espa?ola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaci��n online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
- Cerner Multum, Inc "ANVISA Bul��rio Eletr?nico." O 0 (2015):
- "Product Information. Folic Acid (folic acid)." Method Pharmaceuticals, LLC (2017):
Conditions
Conditions in which Iron Polymaltose Complex + Folic Acid + Zinc Sulfate needs care, as documented in this source.
Anemia
MajorThe use of folic acid is contraindicated in patients with undiagnosed anemia. Folic acid in dosages above 1 mg/day can obscure the diagnosis of pernicious anemia by alleviating the hematologic abnormalities while allowing the progression of neurologic complications. In addition, folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.
3 sources
- Butterworth CE Jr, Tamura T "Folic acid safety and toxicity: a brief review." Am J Clin Nutr 50 (1989): 353-8
- Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095
- "Product Information. Renal Multivitamin Formula Rx (folic acid)." Vitaline Corporation, Ashland, OR.
Kidney Diseases
ModerateThe trace metals, chromium and zinc, are excreted primarily in the urine. Selenium is partially excreted in the urine. Supplemental doses of these agents may need to be adjusted, reduced, or omitted in patients with renal dysfunction.
3 sources
- "Product Information. Galzin (zinc acetate)." Teva Pharmaceuticals USA (2001):
- "Product Information. Chroma-Pak (chromic chloride hexahydrate)." Apothecon Inc (2022):
- "Product Information. Sele-Pak (selenium)." Fujisawa
Malabsorption Syndromes
ModerateThe trace metals manganese, chromium, copper, selenium, and zinc are absorbed in the GI tract from dietary sources and following administration of oral supplements. GI absorption may be decreased in patients with malabsorption syndromes. Therefore, larger dosages may be required when these supplements are given orally. Parenteral administration may be appropriate.
6 sources
- "Product Information. Galzin (zinc acetate)." Teva Pharmaceuticals USA (2001):
- "Product Information. Chroma-Pak (chromic chloride hexahydrate)." Apothecon Inc (2022):
- "Product Information. Sele-Pak (selenium)." Fujisawa
- "Product Information. Copper Sulfate (copper sulfate)." Humco Holding Group (2001):
- "Product Information. Manganese Chloride (manganese chloride)." Abbott Pharmaceutical (2001):
- "Product Information. Manganese Sulfate (manganese sulfate)." American Regent Laboratories Inc (2001):