Daprodustat interactions
Full monograph for DaprodustatCheck it against another medicine
Medicines
105 documented
Mechanism
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Abiraterone Acetate | Major | Metabolism | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Clopidogrel + Aspirin | Major | Metabolism · Synergy | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with…2 documented mechanisms | 2 sources — open the full entry |
| Clopidogrel Bisulphate | Major | Metabolism | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Deferasirox | Major | Metabolism | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Gemfibrozil | Major | Metabolism | Coadministration with potent inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Leflunomide | Major | Metabolism | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Mifepristone | Major | Metabolism | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Mifepristone + Misoprostol | Major | Metabolism | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Selpercatinib | Major | Metabolism | Coadministration with moderate inhibitors of CYP450 2C8 may significantly increase the plasma concentrations and the risk of adverse effects associated with… | 1 sources — open the full entry |
| Acyclovir + Hydrocortisone | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Alendronic acid | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Alendronic Acid + Vitamin D3 | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Asciminib | Moderate | Metabolism | Coadministration with inhibitors of CYP450 2C8 may increase the plasma concentrations and the risk of adverse effects associated with daprodustat, which is… | 1 sources — open the full entry |
| Aspirin | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Aspirin + Dipyridamole | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Benzoic Acid + Salicylic Acid | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone + Calcipotriol | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone + Neomycin Sulphate (Ophthalmic) | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone + Phenylephrine + Lignocaine | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone Dipropionate | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone Dipropionate + Salicylic Acid | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal…2 documented mechanisms | 1 sources — open the full entry |
| Betamethasone Sodium Phosphate | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Betamethasone Valerate | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Bromfenac Sodium | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| BudesonideInhalerNebuliser SuspensionTablet | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Budesonide + Formoterol Fumarate | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumarate | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Calcium Dobesilate + Lidocaine + Dexamethasone | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Framycetin + Esculin | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Neomycin + Esculin | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Ciprofloxacin + Dexamethasone | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Clobetasol Propionate + Salicylic Acid | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Clotrimazole + Hydrocortisone | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Coal Tar + Precipitated Sulphur + Salicylic Acid | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Deflazacort | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexamethasone | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexamethasone + Chloramphenicol | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexamethasone + Levofloxacin | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexamethasone + Neomycin + Glacial Acetic Acid | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexamethasone + Neomycin Sulphate + Polymyxin B Sulphate | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexamethasone + Tobramycin | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexibuprofen | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Dexketoprofen | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Diclofenac Diethylamine + Mephenesin + Menthol + Methyl Salicylate + Turpentine Oil | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Diclofenac Potassium | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Diclofenac Sodium | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
| Diclofenac Sodium + Lidocaine Hydrochloride | Moderate | Synergy | Coadministration of daprodustat with drugs that are known to increase the risk of gastrointestinal erosion may increase the risk of gastric or esophageal… | 1 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Smoking and alcohol consumption during therapy with daprodustat may increase the risk of gastric or esophageal erosions.
What to do: Caution is advised if daprodustat is prescribed to current tobacco smokers or alcohol drinkers. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.
1 source
- "Product Information. Jesduvroq (daprodustat)." GlaxoSmithKline (2023):
cigarette
ModerateSynergy
Smoking and alcohol consumption during therapy with daprodustat may increase the risk of gastric or esophageal erosions.
What to do: Caution is advised if daprodustat is prescribed to current tobacco smokers or alcohol drinkers. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.
1 source
- "Product Information. Jesduvroq (daprodustat)." GlaxoSmithKline (2023):