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Deflazacort interactions

Full monograph for DeflazacortCheck it against another medicine

Medicines

329 documented

Medicines documented to interact with Deflazacort, worst severity first.
MedicineSeverityMechanismEffectSources
AdalimumabMajorSynergyThe use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections…6 sources — open the full entry
ApalutamideMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
AprepitantMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
BaricitinibMajorOthersCoadministration of baricitinib or tofacitinib with other immuno- or myelosuppressive agents may potentiate the risk of infections as well as lymphoma and…6 sources — open the full entry
Bempedoic acidMajorSynergyConcomitant administration of bempedoic acid may potentiate the risk of tendon rupture or injury associated with fluoroquinolones and corticosteroids. The…2 sources — open the full entry
Bempedoic acid + EzetimibeMajorSynergyConcomitant administration of bempedoic acid may potentiate the risk of tendon rupture or injury associated with fluoroquinolones and corticosteroids. The…2 sources — open the full entry
Bosentan MonohydrateMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
Bupropion HydrochlorideMajorSynergyThe use of bupropion is associated with a dose-related risk of seizures. The risk may be further increased when coadministered with selective serotonin…19 sources — open the full entry
Calcium Dobesilate + Lidocaine + DexamethasoneMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
CarbamazepineMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
CenobamateMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
CeritinibMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
CiprofloxacinbaseOphthalmicMajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry
Ciprofloxacin + DexamethasoneMajorMetabolism · SynergyCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…2 documented mechanisms13 sources — open the full entry
Ciprofloxacin + Hydrocortisone AcetateMajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry
ClarithromycinMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
Clobetasol Propionate + Ofloxacin + Ornidazole + TerbinafineMajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry
CrizotinibMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
DeferasiroxMajorSynergyCoadministration with drugs that have known ulcerogenic or hemorrhagic potential may increase the risk of gastrointestinal bleeding associated with the use of…3 sources — open the full entry
DelafloxacinMajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry
Desmopressin AcetateMajorSynergyCoadministration of desmopressin with loop diuretics or systemic or inhaled corticosteroids may increase the risk of severe hyponatremia. Loop diuretics and…9 sources — open the full entry
DexamethasoneMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
Dexamethasone + ChloramphenicolMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
Dexamethasone + LevofloxacinMajorMetabolism · SynergyCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…2 documented mechanisms13 sources — open the full entry
Dexamethasone + Neomycin + Glacial Acetic AcidMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
Dexamethasone + Neomycin Sulphate + Polymyxin B SulphateMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
Dexamethasone + TobramycinMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
Dextromethorphan + BupropionMajorSynergyThe use of bupropion is associated with a dose-related risk of seizures. The risk may be further increased when coadministered with selective serotonin…19 sources — open the full entry
Diltiazem HydrochlorideMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
EfavirenzMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
EnzalutamideMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
ErythromycinLotionOralMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
Esomeprazole + Amoxicillin + ClarithromycinMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
EtanerceptMajorSynergyThe use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections…6 sources — open the full entry
FluconazolebaseOphthalmicMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
Fosphenytoin SodiumMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
GatifloxacinMajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry
Gatifloxacin + DexamethasoneMajorMetabolism · SynergyCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…2 documented mechanisms13 sources — open the full entry
GemifloxacinMajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry
GolimumabMajorSynergyThe use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections…6 sources — open the full entry
Imatinib MesylateMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
InfliximabMajorSynergyThe use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections…6 sources — open the full entry
ItraconazoleMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
KetoconazoleMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
Ketoconazole + Zinc Pyrithione + AleoveraMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
Lamivudine + Zidovudine + NevirapineMajorMetabolismCoadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active…6 sources — open the full entry
Lansoprazole + Amoxicillin + ClarithromycinMajorMetabolismCoadministration with potent or moderate inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of 21-desdeflazacort, the active…3 sources — open the full entry
LeflunomideMajorSynergyThe use of leflunomide with other immunosuppressive or myelosuppressive agents may increase the risk of infections. The risk is thought to extend to…2 sources — open the full entry
Levofloxacin (Eye/Ear)MajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry
Levofloxacin HemihydrateMajorSynergyConcomitant administration of corticosteroids may potentiate the risk of tendinitis and tendon rupture associated with fluoroquinolone treatment. The mechanism…7 sources — open the full entry

Food & lifestyle

Conditions

Conditions in which Deflazacort needs care, as documented in this source.