Articaine Hydrochloride + Epinephrine Bitartrate interactions
Checked as Articaine + Epinephrine in this data source.
Full monograph for Articaine Hydrochloride + Epinephrine BitartrateCheck it against another medicine
Medicines
469 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Amitriptyline Hydrochloridevia Epinephrine | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxidevia Articaine, Epinephrine | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing…3 documented mechanisms | 21 sources — open the full entry |
| Bimatoprost + Timololvia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Brimonidine Tartrate + Timolol Maleatevia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Brinzolamide + Timololvia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Bupivacaine Hydrochloridevia Articaine, Epinephrine | Major | Synergy · Unknown | Additive toxicities may occur when bupivacaine is coadministered with other local anesthetics. The potential for increased risk of systemic toxicities such as…2 documented mechanisms | 3 sources — open the full entry |
| Bupivacaine Hydrochloride + Dextrosevia Articaine, Epinephrine | Major | Synergy · Unknown | Additive toxicities may occur when bupivacaine is coadministered with other local anesthetics. The potential for increased risk of systemic toxicities such as…2 documented mechanisms | 3 sources — open the full entry |
| Carvedilolvia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Chloroquine Phosphatevia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Clomipramine Hydrochloridevia Epinephrine | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Cyclophosphamidevia Articaine, Epinephrine | Major | Synergy · Unknown | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine…2 documented mechanisms | 5 sources — open the full entry |
| Dapsonevia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Dorzolamide + Timololvia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Doxepin (Oral)via Epinephrine | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Ergometrine Maleatevia Epinephrine | Major | Synergy | Additive or synergistic increases in blood pressure and/or ischemic response may occur when ergot alkaloids are combined with peripheral or central… | 38 sources — open the full entry |
| Fluphenazine + Nortriptylinevia Epinephrine | Major | Antagonism · Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing…2 documented mechanisms | 33 sources — open the full entry |
| Flutamidevia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Halothanevia Epinephrine | Major | Others | Rarely, the combination of epinephrine and some anesthetics has resulted in ventricular irritability, serious cardiac arrhythmias, or death. The halogenated… | 20 sources — open the full entry |
| Hydroxyureavia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Ifosfamidevia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Imipramine Hydrochloridevia Epinephrine | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Isofluranevia Epinephrine | Major | Others | Rarely, the combination of epinephrine and some anesthetics has resulted in ventricular irritability, serious cardiac arrhythmias, or death. The halogenated… | 20 sources — open the full entry |
| Isosorbide Dinitrate + Hydralazine Hydrochloridevia Articaine, Epinephrine | Major | Synergy · Unknown | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine…2 documented mechanisms | 5 sources — open the full entry |
| Isosorbide Mononitratevia Articaine, Epinephrine | Major | Synergy · Unknown | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine…2 documented mechanisms | 5 sources — open the full entry |
| Labetalol Hydrochloridevia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Latanoprost + Timololvia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Linezolidvia Epinephrine | Major | Synergy | Linezolid may potentiate the pressor response to sympathomimetic agents. Linezolid is a reversible, nonselective monoamine oxidase inhibitor (MAOI) and, as… | 24 sources — open the full entry |
| Methylergonovine Maleatevia Epinephrine | Major | Synergy | Additive or synergistic increases in blood pressure and/or ischemic response may occur when ergot alkaloids are combined with peripheral or central… | 38 sources — open the full entry |
| Metoclopramide Hydrochloridevia Articaine, Epinephrine | Major | Synergy · Unknown | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine…2 documented mechanisms | 5 sources — open the full entry |
| Nitrofurantoinvia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Nitrofurantoin + Nitrofurantoin Microcrystalsvia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| NitroglycerinbaseIV InfusionOintmentvia Articaine, Epinephrine | Major | Synergy · Unknown | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine…2 documented mechanisms | 5 sources — open the full entry |
| Nortriptylinevia Epinephrine | Major | Synergy | Tricyclic antidepressants (TCAs) may markedly enhance the pressor response to parenteral direct-acting sympathomimetic agents and vasoconstrictor-containing… | 11 sources — open the full entry |
| Phenobarbitalvia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Phenytoin Sodiumvia Articaine, Epinephrine | Major | Synergy · Unknown | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine…2 documented mechanisms | 5 sources — open the full entry |
| Primaquine Phosphatevia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Propranolol Hydrochloridevia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Quinine Sulfatevia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Sevofluranevia Epinephrine | Major | Others | Rarely, the combination of epinephrine and some anesthetics has resulted in ventricular irritability, serious cardiac arrhythmias, or death. The halogenated… | 20 sources — open the full entry |
| Sotalol Hydrochloridevia Articaine, Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors…2 documented mechanisms | 27 sources — open the full entry |
| Sulfasalazinevia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine… | 5 sources — open the full entry |
| Sulphamethoxazole + Trimethoprimvia Articaine | Major | Synergy | Coadministration of local anesthetics with other oxidizing agents that can also induce methemoglobinemia such as antimalarials (e.g., chloroquine, primaquine…2 documented mechanisms | 5 sources — open the full entry |
| Timolol Maleatevia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Travoprost + Timolol Maleatevia Epinephrine | Major | Synergy | Noncardioselective beta-blockers can significantly enhance the pressor response to epinephrine. The mechanism involves blockade of beta-2 adrenergic receptors… | 25 sources — open the full entry |
| Acarbosevia Epinephrine | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Aclidinium Bromide + Formoterol Fumaratevia Epinephrine | Moderate | Synergy | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists… | 11 sources — open the full entry |
| Alogliptin Benzoatevia Epinephrine | Moderate | Antagonism | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics… | 95 sources — open the full entry |
| Alprazolamvia Articaine, Epinephrine | Moderate | Synergy · Unknown | The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.3 documented mechanisms | 10 sources — open the full entry |
| Amiodarone Hydrochloridevia Articaine, Epinephrine | Moderate | Synergy · Unknown | Amide-type local anesthetics may have additive cardiac effects (e.g., bradycardia, chest pain, heart block, arrhythmias, ECG abnormalities, cardiac arrest)…3 documented mechanisms | 4 sources — open the full entry |
| Amisulpridevia Epinephrine | Moderate | Antagonism | Phenothiazines and other neuroleptics may inhibit or reverse the pressor effect of adrenaline (epinephrine), dopamine, and similar vasoconstrictors. Many of… | 22 sources — open the full entry |
Conditions
Conditions in which Articaine Hydrochloride + Epinephrine Bitartrate needs care, as documented in this source.
Cardiovascular Diseases
MajorSympathomimetic agents may cause adverse cardiovascular effects, particularly when used in high dosages and/or in susceptible patients. In cardiac tissues, these agents may produce positive chronotropic and inotropic effects via stimulation of beta- 1 adrenergic receptors. Cardiac output, oxygen consumption, and the work of the heart may be increased. In the peripheral vasculature, vasoconstriction may occur via stimulation of alpha-1 adrenergic receptors. Palpitations, tachycardia, arrhythmia, hypertension, reflex bradycardia, coronary occlusion, cerebral vasculitis, myocardial infarction, cardiac arrest, and death have been reported. Some of these agents, particularly ephedra alkaloids (ephedrine, ma huang, phenylpropanolamine), may also predispose patients to hemorrhagic and ischemic stroke. Therapy with sympathomimetic agents should generally be avoided or administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, or underlying cardiovascular or cerebrovascular disorders. These agents should not be used in patients with severe coronary artery disease or severe/uncontrolled hypertension.
58 sources
- Humberstone PM "Hypertension from cold remedies." Br Med J 1 (1969): 846
- Mariani PJ "Pseudoephedrine-induced hypertensive emergency: treatment with labetalol." Am J Emerg Med 4 (1986): 141-2
- Rosen RA "Angina associated with pseudoephedrine ." Ann Emerg Med 10 (1981): 230-1
- Wiener I, Tilkian AG, Palazzolo M "Coronary artery spasm and myocardial infarction in a patient with normal coronary arteries: temporal relationship to pseudoephedrine ingestion." Cathet Cardiovasc Diagn 20 (1990): 51-3
- Gordon RD, Ballantine DM, Bachmann AW "Effects of repeated doses of pseudoephedrine on blood pressure and plasma catecholamines in normal subjects and in patients with phaeochromocytoma." Clin Exp Pharmacol Physiol 19 (1992): 287-90
- Loizou LA, Hamilton JG, Tsementzis SA "Intracranial haemorrhage in association with pseudoephedrine overdose." J Neurol Neurosurg Psychiatry 45 (1982): 471-2
- Dickerson J, Perrier D, Mayersohn M, Bressler R "Dose tolerance and pharmacokinetic studies of L (+) pseudoephedrine capsules in man." Eur J Clin Pharmacol 14 (1978): 253-9
- Wooten MR, Khangure MS, Murphy MJ "Intracerebral hemorrhage and vasculitis related to ephedrine abuse." Ann Neurol 13 (1983): 337-40
Show all 58 sourcesShow fewer sources
- To LB, Sangster JF, Rampling D, Cammens I "Ephedrine-induced cardiomyopathy." Med J Aust 2 (1980): 35-6
- Bruno A, Nolte KB, Chapin J "Stroke associated with ephedrine use." Neurology 43 (1993): 1313-6
- Stoessl AJ, Young GB, Feasby TE "Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics." Stroke 16 (1985): 734-6
- Covington TR, eds., Lawson LC, Young LL "Handbook of Nonprescription Drugs." Washington, DC: American Pharmaceutical Association (1993):
- "Product Information. Sudafed (pseudoephedrine)." Glaxo Wellcome (2001):
- Kizer KW "Intracranial hemorrhage associated with overdose of decongestant containing phenylpropanolamine" Am J Emerg Med 2 (1984): 180-1
- Edwards M, Russo L, Harwood-Nuss A "Cerebral infarction with a single oral dose of phenylpropanolamine." Am J Emerg Med 5 (1987): 163-4
- Lake CR, Gallant S, Masson E, Miller P "Adverse drug effects attributed to phenylpropanolamine: a review of 142 case reports." Am J Med 89 (1990): 195-208
- Lake CR, Zaloga G, Bray J, Rosenberg D, Chernow B "Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: a placebo-controlled follow-up study." Am J Med 86 (1989): 427-32
- Lake CR, Zaloga G, Clymer R, Quirk RM, Chernow B "A double dose of phenylpropanolamine causes transient hypertension." Am J Med 85 (1988): 339-43
- Bernstein E, Diskant BM "Phenylpropanolamine: a potentially hazardous drug." Ann Emerg Med 11 (1982): 311-5
- Kroenke K, Omori DM, Simmons JO, Wood DR, Meier NJ "The safety of phenylpropanolamine in patients with stable hypertension." Ann Intern Med 111 (1989): 1043-4
- Pentel PR, Mikell FL, Zavoral JH "Myocardial injury after phenylpropanolamine ingestion." Br Heart J 47 (1982): 51-4
- Howrie DL, Wolfson JH "Phenylpropanolamine-induced hypertensive seizures." J Pediatr 102 (1983): 143-5
- Horowitz JD, Lang WJ, Howes LG, Fennessy MR, Christophidis N, Rand MJ, Louis WJ "Hypertensive responses induced by phenylpropanolamine in anorectic and decongestant preparations." Lancet 1 (1980): 60-1
- Johnson DA, Etter HS, Reeves DM "Stroke and phenylpropanolamine use" Lancet 2 (1983): 970
- McEwen J "Phenylpropanolamine-associated hypertension after the use of "over- the-counter" appetite-suppressant products." Med J Aust 2 (1983): 71-3
- Elliott CF, Whyte JC "Phenylpropanolamine and hypertension." Med J Aust 1 (1981): 715
- Maher LM, Peterson PL, Dela-Cruz C "Postpartum intracranial hemorrhage and phenylpropanolamine use" Neurology 37 (1987): 1686
- Kase CS, Foster TE, Reed JE, Spatz EL, Girgis GN "Intracerebral hemorrhage and phenylpropanolamine use." Neurology 37 (1987): 399-404
- Kikta DG, Devereaux MW, Chandar K "Intracranial hemorrhages due to phenylpropanolamine." Stroke 16 (1985): 510-2
- Clark JE, Simon WA "Cardiac arrhythmias after phenylpropanolamine ingestion." Drug Intell Clin Pharm 17 (1983): 737-8
- Noble R "A controlled clinical trial of the cardiovascular and psychological effects of phenylpropanolamine and caffeine." Drug Intell Clin Pharm 22 (1988): 296-9
- O'Connell MB, Gross CR "The effect of multiple doses of phenylpropanolamine on the blood pressure of patients whose hypertension was controlled with beta blockers." Pharmacotherapy 11 (1991): 376-81
- O'Connell MB, Gross CR "The effect of single-dose phenylpropanolamine on blood pressure in patients with hypertension controlled by beta blockers." Pharmacotherapy 10 (1990): 85-91
- Chin C, Choy M "Cardiomyopathy induced by phenylpropanolamine." J Pediatr 123 (1993): 825-7
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
- Lee KY, Beilin LJ, Vandongen R "Severe hypertension after ingestion of an appetite suppressant (phenylpropanolamine) with indomethacin." Lancet 1 (1979): 1110-1
- Gibson GJ, Warrell DA "Hypertensive crises and phenylpropanolamine." Lancet 2 (1972): 492-3
- Frewin DB "Phenylpropanolamine. How safe is it?" Med J Aust 2 (1983): 54-5
- Lee KY, Beilin LJ, Vandongen R "Severe hypertension after administration of phenylpropanolamine" Med J Aust 1 (1979): 525-6
- Horowitz JD, McNeil JJ, Sweet B, Mendelsohn FA, Louis WJ "Hypertension and postural hypotension induced by phenylpropanolamine (Trimolets)." Med J Aust 1 (1979): 175-6
- Frewin DB, Leonello PP, Frewin ME "Hypertension after ingestion of Trimolets." Med J Aust 2 (1978): 497-8
- Teh AY "Phenylpropanolamine and hypertension" Med J Aust 2 (1979): 425-6
- Shapiro SR "Hypertension due to anorectic agent." N Engl J Med 280 (1969): 1363
- Maher LM, Peterson PL, Dela-Cruz C "Postpartum intracranial hemorrhage and phenylpropanolamine use." Neurology 37 (1987): 1886,1890
- Fallis RJ, Fisher M "Cerebral vasculitis and hemorrhage associated with phenylpropanolamine." Neurology 35 (1985): 405-7
- Caperton E "Raynaud's phenomenon. Role of diet pills and cold remedies." Postgrad Med 73 (1983): 291-2
- McDowell JR, LeBlanc HJ "Phenylpropanolamine and cerebral hemorrhage." West J Med 142 (1985): 688-91
- Williams DM "Phenylpropanolamine hydrochloride" Am Pharm NS30 (1990): 47-50
- Dowse R, Scherzinger SS, Kanfer I "Serum concentrations of phenylpropanolamine and associated effects on blood pressure in normotensive subjects: a pilot-study." Int J Clin Pharmacol Ther Toxicol 28 (1990): 205-10
- Pentel PR, Aaron C, Paya C "Therapeutic doses of phenylpropanolamine increase supine systolic blood pressure." Int J Obes 9 (1985): 115-9
- Finton CK, Barton M, Chernow B "Possible adverse effects of phenylpropanolamine (diet pills) on sympathetic nervous system function--caveat emptor!" Mil Med 147 (1982): 1072
- "Product Information. Adrenalin (EPINEPHrine)." Apothecon Inc (2022):
- Leo PJ, Hollander JE, Shih RD, Marcus SM "Phenylpropanolamine and associated myocardial injury." Ann Emerg Med 28 (1996): 359-62
- Gill ND, Shield A, Blazevich AJ, Zhou S, Weatherby RP "Muscular and cardiorespiratory effects of pseudoephedrine in human athletes." Br J Clin Pharmacol 50 (2000): 205-13
- Haller CA, Benowitz NL "Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids." N Engl J Med 343 (2000): 1833-8
- Mansoor GA "Herbs and alternative therapies in the hypertension clinic." Am J Hypertens 14(9 Pt 1) (2001): 971-5
- Samenuk D, Link MS, Homoud MK, et al. "Adverse cardiovascular events temporally associated with ma huang, an herbal source of ephedrine." Mayo Clin Proc 77 (2002): 12-6
- "Product Information. Akovaz (ephedrine)." Eclat Pharmaceuticals (2016):
Dehydration
MajorThe use of sympathomimetic amines has been infrequently associated with significant hypotension especially in dehydrated patients secondary to the drug's beta-2 mediated vasodilation. Hypovolemia should be corrected, if possible, before administering sympathomimetic amines. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.
4 sources
- "Product Information. Isuprel (isoproterenol)." Sanofi Winthrop Pharmaceuticals (2001):
- "Product Information. Epifrin (EPINEPHrine ophthalmic)." Allergan Inc (2022):
- "Product Information. Adrenalin (EPINEPHrine)." Apothecon Inc (2022):
- "Product Information. Levophed Bitartrate (norepinephrine)." Sanofi Winthrop Pharmaceuticals (2001):
Acidosis
ModerateAcidosis, hypoxia, and hypercapnia may reduce the effectiveness of sympathomimetic amines in raising blood pressure. These conditions should be corrected before initiating therapy with sympathomimetic amines, if possible. Monitoring the patients acid-base balance, carbon dioxide levels, and oxygen saturation is recommended.
4 sources
- "Product Information. Isuprel (isoproterenol)." Sanofi Winthrop Pharmaceuticals (2001):
- "Product Information. Epifrin (EPINEPHrine ophthalmic)." Allergan Inc (2022):
- "Product Information. Adrenalin (EPINEPHrine)." Apothecon Inc (2022):
- "Product Information. Levophed Bitartrate (norepinephrine)." Sanofi Winthrop Pharmaceuticals (2001):
Diabetes Mellitus
ModerateSympathomimetic agents may cause increases in blood glucose concentrations. These effects are usually transient and slight but may be significant with dosages higher than those normally recommended. Therapy with sympathomimetic agents should be administered cautiously in patients with diabetes mellitus. Closer monitoring of blood glucose concentrations may be appropriate.
6 sources
- Covington TR, eds., Lawson LC, Young LL "Handbook of Nonprescription Drugs." Washington, DC: American Pharmaceutical Association (1993):
- "Product Information. Sudafed (pseudoephedrine)." Glaxo Wellcome (2001):
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
- Williams DM "Phenylpropanolamine hydrochloride" Am Pharm NS30 (1990): 47-50
- "Product Information. Adrenalin (EPINEPHrine)." Apothecon Inc (2022):
- "Product Information. Akovaz (ephedrine)." Eclat Pharmaceuticals (2016):
Parkinson Disease
ModerateEpinephrine should be administered with caution to patients with Parkinson's disease as these patients may experience psychomotor agitation or notice a temporary worsening of symptoms.
1 source
- "Product Information. Adrenalin (EPINEPHrine)." Apothecon Inc (2022):
Therapeutic duplication
Drug classes that overlap with Articaine Hydrochloride + Epinephrine Bitartrate, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Olodaterol/tiotropium
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Wixela inhub
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Formoterol/mometasone
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Glycopyrrolate/indacaterol
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Trelegy ellipta
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Fluticasone/vilanterol
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Symbicort
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Duaklir pressair
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Budesonide/formoterol/glycopyrrolate
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Albuterol/ipratropium
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Anoro ellipta
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Albuterol/budesonide
inhaled smooth muscle relaxants
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'inhaled smooth muscle relaxants' category.
Example product in the source data (US market): Formoterol/glycopyrrolate
sympathomimetic amines
The recommended maximum number of medicines in the 'sympathomimetic amines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'sympathomimetic amines' category.
Example product in the source data (US market): Guaifenex
sympathomimetic amines
The recommended maximum number of medicines in the 'sympathomimetic amines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'sympathomimetic amines' category.
Example product in the source data (US market): Promethazine vc with codeine
sympathomimetic amines
The recommended maximum number of medicines in the 'sympathomimetic amines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'sympathomimetic amines' category.
Example product in the source data (US market): Phenylephrine/promethazine