Pomalidomide interactions

Food & lifestyle

• cigarette

  Moderate

  Metabolism

  Cigarette smoking may reduce pomalidomide exposure due to induction of CYP450 1A2, the isoenzyme that is responsible for the metabolic clearance of pomalidomide along with CYP450 3A4.

  What to do: Patients should be advised that smoking may reduce the efficacy of pomalidomide therapy. Pomalidomide should be taken on an empty stomach, at least 2 hours before or 2 hours after a meal.

  1 source

  1. "Product Information. Pomalyst (pomalidomide)." QLT Phototherapeutics Inc (2013):

Conditions

Conditions in which Pomalidomide needs care, as documented in this source.

• Thromboembolism

  Major

  Pomalidomide may cause venous thromboembolic events (deep venous thrombosis and pulmonary embolism) and arterial thromboembolic events (myocardial infarction and stroke). It is recommended to initiate precautionary actions to try to minimize all modifiable factors (e.g., hyperlipidemia, hypertension, smoking) in patients with known risk factors, including those with prior thrombosis. Thromboprophylaxis is recommended, and the choice of regimen should be based on the assessment of the patient's underlying risk factors.

  1 source

  1. "Product Information. Pomalyst (pomalidomide)." QLT Phototherapeutics Inc (2013):

• Hepatic Insufficiency

  Moderate

  Pomalidomide is primarily metabolized in the liver by CYP450 1A2 and CYP450 3A4. Hepatic failure, including fatal cases, has occurred in patients treated with pomalidomide. Elevated levels of alanine aminotransferase and bilirubin have also been observed. Reduce the starting dose of pomalidomide by 25% (3 mg daily) in patients with mild to moderate hepatic impairment and by 50% (2 mg daily) in those patients with severe hepatic impairment. It is recommended to monitor liver function tests monthly and to stop treatment with pomalidomide upon elevation of liver enzymes. After return to baseline values, treatment at a lower dose may be considered.

  1 source

  1. "Product Information. Pomalyst (pomalidomide)." QLT Phototherapeutics Inc (2013):

• Kidney Diseases

  Moderate

  Pomalidomide pharmacokinetic parameters were not significantly affected in patients with moderate or severe renal impairment. Pomalidomide should be used with caution in patients with severe renal impairment requiring dialysis and it should be administered after the completion of hemodialysis on dialysis days as the exposure of the drug could be significantly increased. Dose modification, 25% dose reduction (3 mg daily) is recommended at the start of therapy in patients with severe renal impairment requiring dialysis. Close monitoring is recommended.

  1 source

  1. "Product Information. Pomalyst (pomalidomide)." QLT Phototherapeutics Inc (2013):

• Neutropenia

  Moderate

  The use of pomalidomide has been associated with hematological toxicities, followed by anemia and thrombocytopenia. It is recommended to monitor patients for hematologic toxicities, especially neutropenia. Monitor complete blood counts weekly for the first 8 weeks and monthly thereafter and depending on findings, patients may require dose interruption and/or modification. Close monitoring is recommended.

  1 source

  1. "Product Information. Pomalyst (pomalidomide)." QLT Phototherapeutics Inc (2013):

• Peripheral Nervous System Diseases

  Moderate

  The use of pomalidomide has been associated with the development of neuropathy. Therapy with pomalidomide should be administered cautiously in patients with or at risk for neuropathy. Monitor closely for signs and symptoms associated with neuropathy and evaluate patients accordingly.

  1 source

  1. "Product Information. Pomalyst (pomalidomide)." QLT Phototherapeutics Inc (2013):

• Tumor Lysis Syndrome

  Moderate

  Tumor lysis syndrome (TLS) may occur in patients receiving pomalidomide. Patients with high tumor burden and those with high circulating lymphocyte counts of greater than 25 X 10^9/L have a higher risk of developing TLS. Monitor for signs and symptoms of TLS. Temporary interruption or discontinuation of therapy might be required.

  1 source

  1. "Product Information. Pomalyst (pomalidomide)." QLT Phototherapeutics Inc (2013):