Piperacillin + Tazobactam interactions
Checked as Piperacillin + Tazobactam in this data source.
Full monograph for Piperacillin + TazobactamCheck it against another medicine
Medicines
239 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Methotrexatevia Piperacillin | Major | Excretion | Concomitant use of large doses of penicillins may elevate serum methotrexate concentrations. The mechanism may involve competitive inhibition of renal tubular… | 11 sources — open the full entry |
| Vancomycin Hydrochloridevia Piperacillin | Major | Synergy | When administered concomitantly, vancomycin and piperacillin may have additive nephrotoxic effects. A limited number of retrospective studies have found an… | 11 sources — open the full entry |
| Amikacinvia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Atracurium Besilatevia Piperacillin | Moderate | Others | Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in… | 8 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocainevia Piperacillin | Moderate | Antagonism · Unknown | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol…2 documented mechanisms | 4 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicinvia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Chloramphenicol (Oral)via Piperacillin | Moderate | Antagonism | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol… | 4 sources — open the full entry |
| Chloramphenicol + Lidocaine Hydrochloridevia Piperacillin | Moderate | Antagonism · Unknown | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol…2 documented mechanisms | 4 sources — open the full entry |
| Cisatracurium Besylatevia Piperacillin | Moderate | Others | Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in… | 8 sources — open the full entry |
| Cyproterone Acetate + Ethinyl Estradiolvia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Dexamethasone + Chloramphenicolvia Piperacillin | Moderate | Antagonism · Unknown | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol…2 documented mechanisms | 4 sources — open the full entry |
| Dexamethasone + Tobramycinvia Piperacillin | Moderate | Others · Unknown | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is…2 documented mechanisms | 17 sources — open the full entry |
| Dienogest + Estradiol Valeratevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Doxycycline Hydrochloridevia Piperacillin | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Drospirenone + Estradiolvia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol0.02 mg0.03 mgvia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol + Levomefolatevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Entecavir Monohydratevia Tazobactam, Piperacillin | Moderate | Excretion | Coadministration of entecavir with another drug that is also eliminated by active tubular secretion may result in increased plasma concentrations of one or…2 documented mechanisms | 2 sources — open the full entry |
| Estradiolbasevaginal creamvia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol + Dydrogesteronevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Hemihydrate + Progesterone Micronizedvia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Valeratevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Desogestrel0.02 mg0.03 mgvia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Gestodenevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Levonorgestrel + Ferrous Fumaratevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Lynestrenol0.0375 mg0.05 mgvia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Fluorometholone + Gentamicinvia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Gentamicin + Hydrocortisone Acetatevia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Gentamicin SulfateInjectionOphthalmicvia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Kanamycinvia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Loteprednol Etabonate + Tobramycinvia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Minocycline Hydrochloridevia Piperacillin | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Mycophenolate Mofetilvia Piperacillin | Moderate | Absorption | Theoretically, drugs that alter the gastrointestinal flora (e.g., antibiotics) may reduce the oral bioavailability of mycophenolic acid products. Some… | 3 sources — open the full entry |
| Mycophenolic acidvia Piperacillin | Moderate | Absorption | Theoretically, drugs that alter the gastrointestinal flora (e.g., antibiotics) may reduce the oral bioavailability of mycophenolic acid products. Some… | 3 sources — open the full entry |
| Norgestrel + Ethinyl Estradiol + Ferrous Fumaratevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Oxytetracyclinevia Piperacillin | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Oxytetracycline + Polymixin B Sulphatevia Piperacillin | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Pancuronium Bromidevia Piperacillin | Moderate | Others | Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in… | 8 sources — open the full entry |
| Pemetrexedvia Piperacillin | Moderate | Excretion | Coadministration with drugs that are eliminated by active tubular secretion may delay and/or decrease the clearance of pemetrexed. The mechanism is competitive… | 1 sources — open the full entry |
| Relugolix + Estradiol + Norethindronevia Piperacillin | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Rocuronium Bromidevia Piperacillin | Moderate | Others | Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in… | 8 sources — open the full entry |
| Suxamethonium Chloridevia Piperacillin | Moderate | Others | Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in… | 8 sources — open the full entry |
| Tetracycline Hydrochloridevia Piperacillin | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| TobramycinNebuliser SolutionOphthalmicvia Piperacillin | Moderate | Others | INTERVAL: Piperacillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is… | 17 sources — open the full entry |
| Vecuronium Bromidevia Piperacillin | Moderate | Others | Piperacillin may prolong the effects of nondepolarizing muscle relaxants. The mechanism is unknown, but small trials and case reports have provided data in… | 8 sources — open the full entry |
| Warfarin Sodiumvia Piperacillin | Moderate | Synergy | Penicillins may occasionally potentiate the risk of bleeding in patients treated with oral anticoagulants. The exact mechanism of interaction is unknown but… | 54 sources — open the full entry |
| Allium cepa + Heparin + Allantoinvia Piperacillin | Minor | Synergy | Case reports have suggested that intravenous penicillins may intensify the effect of heparin by inhibition of platelet aggregation; however, causality has not… | 3 sources — open the full entry |
| Azithromycin DihydratebaseOphthalmicvia Piperacillin | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| Clarithromycinvia Piperacillin | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| ErythromycinLotionOralvia Piperacillin | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
Therapeutic duplication
Drug classes that overlap with Piperacillin + Tazobactam, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
beta-lactam antibiotics
The recommended maximum number of medicines in the 'beta-lactam antibiotics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'beta-lactam antibiotics' category.
Example product in the source data (US market): Prevpac
beta-lactam antibiotics
The recommended maximum number of medicines in the 'beta-lactam antibiotics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'beta-lactam antibiotics' category.
Example product in the source data (US market): Amoxicillin/clarithromycin/omeprazole
beta-lactam antibiotics
The recommended maximum number of medicines in the 'beta-lactam antibiotics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'beta-lactam antibiotics' category.
Example product in the source data (US market): Voquezna triple pak