Ocrelizumab interactions
Full monograph for OcrelizumabCheck it against another medicine
Medicines
181 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Adalimumab | Major | Synergy | The use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections… | 6 sources — open the full entry |
| Baricitinib | Major | Synergy | Coadministration of baricitinib with other immuno- or myelosuppressive agents may potentiate the risk of infections as well as lymphoma and other malignancies… | 4 sources — open the full entry |
| Deucravacitinib | Major | Synergy | Coadministration of deucravacitinib with other immunosuppressive agents may potentiate the risk of infections as well as lymphoma and other malignancies. | 1 sources — open the full entry |
| Etanercept | Major | Synergy | The use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections… | 6 sources — open the full entry |
| Golimumab | Major | Synergy | The use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections… | 6 sources — open the full entry |
| Infliximab | Major | Synergy | The use of tumor necrosis factor (TNF) blockers with other immunosuppressive or myelosuppressive agents may increase the risk of infections. Serious infections… | 6 sources — open the full entry |
| Leflunomide | Major | Synergy | The use of leflunomide with other immunosuppressive or myelosuppressive agents may increase the risk of infections. The risk is thought to extend to… | 2 sources — open the full entry |
| Rotavirus Vaccine | Major | Others | The administration of live, attenuated virus or bacterial vaccines during immunosuppressant therapy may be associated with a risk of disseminated infection due… | 5 sources — open the full entry |
| Tofacitinib | Major | Others | Coadministration of tofacitinib with other immuno- or myelosuppressive agents may potentiate the risk of infections as well as lymphoma and other malignancies… | 1 sources — open the full entry |
| Upadacitinib | Major | Others | Coadministration of upadacitinib with other immuno- or myelosuppressive agents may potentiate the risk of infections as well as lymphoma and other malignancies. | 1 sources — open the full entry |
| Yellow Fever Vaccine | Major | Others · Synergy | The administration of live, attenuated virus or bacterial vaccines during immunosuppressant therapy may be associated with a risk of disseminated infection due…2 documented mechanisms | 10 sources — open the full entry |
| Abemaciclib | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Acalabrutinib | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Acyclovir + Hydrocortisone | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Aflibercept | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Albendazole | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Anti-human T-lymphocyte immunoglobulin | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Anti-Thymocyte Globulin | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Asciminib | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Atezolizumab | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Azacitidine | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Azathioprine | Moderate | Synergy | The use of azathioprine with other immunosuppressive or myelosuppressive agents may result in additive hematologic toxicities and increased risk of infections… | 3 sources — open the full entry |
| Basiliximab | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocaine | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Bendamustine | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone + Calcipotriol | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone + Clotrimazole | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone + Neomycin Sulphate (Ophthalmic) | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone + Phenylephrine + Lignocaine | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone Dipropionate | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone Dipropionate + Salicylic Acid | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone Sodium Phosphate | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Betamethasone Valerate | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Bleomycin Sulfate | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Bortezomib | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Brigatinib | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| BudesonideInhalerNebuliser SuspensionTablet | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Budesonide + Formoterol Fumarate | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumarate | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Cabazitaxel | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Calcium Dobesilate + Lidocaine + Dexamethasone | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Capecitabine | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Carbamazepine | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Carboplatin | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Carfilzomib | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Carmustine | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Chlorambucil | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
| Chloramphenicol (Oral) | Moderate | Synergy | The use of the CD20-directed cytolytic antibody ocrelizumab with other immune-modulating or immunosuppressive therapy, including immunosuppressant doses of… | 1 sources — open the full entry |
Conditions
Conditions in which Ocrelizumab needs care, as documented in this source.
Hepatitis B
MajorThe use of ocrelizumab is contraindicated in patients with an active hepatitis B virus (HBV) infection. It is recommended to consult a liver disease expert before starting and during treatment with ocrelizumab in patients who are negative for surface antigen [HBsAg] and positive for HB core antibody [HBcAb+] or are carriers of HBV [HBsAg+].
1 source
- "Product Information. Ocrevus (ocrelizumab)." Genentech (2017):
Breast Neoplasms
ModerateOcrelizumab may increase the risk of malignancies, including breast cancer. It is recommended to follow standard breast cancer screening guidelines. Exercise care when using this agent in patients with a history of breast cancer or other type of malignancy. Monitor closely for the development of any sign or symptom suggestive of a malignancy and treat appropriately.
1 source
- "Product Information. Ocrevus (ocrelizumab)." Genentech (2017):
Infections
ModerateOcrelizumab may increase the risk for upper respiratory tract infections, lower respiratory tract infections, skin infections, and herpes-related infections. It is recommended to delay the use of ocrelizumab in patients with an active infection until the infection is resolved.
1 source
- "Product Information. Ocrevus (ocrelizumab)." Genentech (2017):
Therapeutic duplication
Drug classes that overlap with Ocrelizumab, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
cd20 monoclonal antibodies
The recommended maximum number of medicines in the 'CD20 monoclonal antibodies' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'CD20 monoclonal antibodies' category.
Example product in the source data (US market): Hyaluronidase/rituximab