Lubiprostone interactions

Conditions

Conditions in which Lubiprostone needs care, as documented in this source.

• Intestinal Obstruction

  Major

  Lubiprostone is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.

  1 source

  1. "Product Information. Amitiza (lubiprostone)." Sucampo Pharmaceuticals Inc (2006):

• Diarrhea

  Moderate

  Lubiprostone should not be prescribed to patients that have severe diarrhea. Care should be exercised when prescribing this drug to patients at risk of diarrhea and patients should be instructed to inform their physician if severe diarrhea occurs.

  1 source

  1. "Product Information. Amitiza (lubiprostone)." Sucampo Pharmaceuticals Inc (2006):

• Dyspnea

  Moderate

  The use of lubiprostone may cause dyspnea. Care should be taken when prescribing this drug to patients that experienced dyspnea or when restarting the drug in those patients experiencing drug induced dyspnea.

  1 source

  1. "Product Information. Amitiza (lubiprostone)." Sucampo Pharmaceuticals Inc (2006):

• Hepatic Insufficiency

  Moderate

  No dosage adjustment is needed in patients with mild hepatic impairment. It is recommended to modify the dose in patients with moderate and severe hepatic impairment as these patients experienced markedly higher systemic drug exposure that can cause an increased incidence and severity of adverse events.

  1 source

  1. "Product Information. Amitiza (lubiprostone)." Sucampo Pharmaceuticals Inc (2006):