Ketamine Hydrochloride interactions
Checked as Ketamine in this data source.
Full monograph for Ketamine HydrochlorideCheck it against another medicine
Medicines
263 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Difelikefalin Acetate | Major | Synergy | Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression… | 3 sources — open the full entry |
| Hyoscine Butylbromide | Major | Synergy | Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression… | 3 sources — open the full entry |
| Hyoscine Hydrobromide | Major | Synergy | Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression… | 3 sources — open the full entry |
| Lacosamide | Major | Synergy | Coadministration of ketamine with other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression… | 3 sources — open the full entry |
| Abametapir | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Aclidinium Bromide + Formoterol Fumarate | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 7 sources — open the full entry |
| Adrenaline | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 3 sources — open the full entry |
| Alpelisib | Moderate | Metabolism | Coadministration with alpelisib may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 2B6. The proposed… | 15 sources — open the full entry |
| Alprazolam | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Amantadine Hydrochloride | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 3 sources — open the full entry |
| Aminophylline | Moderate | Others | Cases of extensor-type seizures have been reported in four asthmatic patients who received aminophylline following induction of anesthesia with ketamine… | 5 sources — open the full entry |
| Amiodarone Hydrochloride | Moderate | Others | Amiodarone may increase the effect of general anesthetics due to its adrenergic blocking effects. Data have been conflicting; however, the potential for… | 6 sources — open the full entry |
| Amitriptyline Hydrochloride | Moderate | Synergy | The concomitant use of general anesthetics with tricyclic antidepressants may increase the risk of hypotension and cardiac arrhythmias. The presence of… | 1 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxide | Moderate | Synergy | The concomitant use of general anesthetics with tricyclic antidepressants may increase the risk of hypotension and cardiac arrhythmias. The presence of…2 documented mechanisms | 45 sources — open the full entry |
| Antazoline + Tetryzoline | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 7 sources — open the full entry |
| Arformoterol Tartrate | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 3 sources — open the full entry |
| Aripiprazole | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Armodafinil | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 3 sources — open the full entry |
| Articaine Hydrochloride + Epinephrine Bitartrate | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 3 sources — open the full entry |
| Asciminib | Moderate | Metabolism | Coadministration with asciminib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is… | 1 sources — open the full entry |
| Asenapine Maleate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Atomoxetine Hydrochloride | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 3 sources — open the full entry |
| Atracurium Besilate | Moderate | Synergy | Ketamine may potentiate the effects of neuromuscular blockers, including respiratory depression. | 7 sources — open the full entry |
| Baclofen | Moderate | Synergy | The concomitant or sequential use of intrathecal baclofen and general anesthetics may increase the risk of seizures and cardiovascular disturbances, and… | 6 sources — open the full entry |
| Beclometasone + Formoterol + Glycopyrronium | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 7 sources — open the full entry |
| Beclomethasone Dipropionate + Formoterol Fumarate | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 7 sources — open the full entry |
| Betamethasone + Phenylephrine + Lignocaine | Moderate | Synergy · Unknown | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index…2 documented mechanisms | 7 sources — open the full entry |
| Brexpiprazole | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Brivaracetam | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Bromocriptine Mesylate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Budesonide + Formoterol Fumarate | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 7 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumarate | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 7 sources — open the full entry |
| Carbamazepine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Carbidopa + LevodopaExtended releaseProlonged release | Moderate | Synergy | Ketamine can cause hemodynamic instability such as arrhythmias and transient increases or decreases in blood pressure, heart rate, and cardiac index… | 7 sources — open the full entry |
| Cariprazine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Carisoprodol | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Cenobamate | Moderate | Metabolism | Coadministration with cenobamate may decrease the plasma concentrations and pharmacologic effects of CYP450 2B6 substrates. The proposed mechanism is… | 13 sources — open the full entry |
| Cetirizine HydrochloridebaseOphthalmic | Moderate | Synergy | Concurrent use of cetirizine or levocetirizine with alcohol or other agents that exhibit central nervous system (CNS) depressant effects may result in additive… | 10 sources — open the full entry |
| Chloral Hydrate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Chlorpheniramine Maleate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Chlorpromazine Hydrochloride | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Cinnarizine + Dimenhydrinate | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Cisatracurium Besylate | Moderate | Synergy | Ketamine may potentiate the effects of neuromuscular blockers, including respiratory depression. | 7 sources — open the full entry |
| Citalopram Hydrobromide | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Clobazam | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Clomipramine Hydrochloride | Moderate | Synergy | The concomitant use of general anesthetics with tricyclic antidepressants may increase the risk of hypotension and cardiac arrhythmias. The presence of… | 1 sources — open the full entry |
| Clonazepam | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Clonidine Hydrochloride | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Clozapine | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
| Cyclizine Hydrochloride | Moderate | Synergy | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these… | 44 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Alcohol may potentiate some of the pharmacologic effects of ketamine. Use in combination may result in additive central nervous system (CNS) depression and/or impairment of judgment, thinking, and psychomotor skills.
What to do: Patients receiving ketamine should not drink alcohol. Caution is advised when ketamine is used in patients with acute alcohol intoxication or a history of chronic alcoholism. Following anesthesia with ketamine, patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination, such as driving or operating hazardous machinery, for at least 24 hours and until they know how the medication affects them. Patients treated with oral ketamine should also avoid consumption of grapefruit and grapefruit juice during treatment. Otherwise, dosage reductions of oral ketamine should be considered.
4 sources
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals (2009):
- Peltoniemi MA, Saari TI, Hagelberg NM, Laine K, Neuvonen PJ, Olkkola KT "S-ketamine concentrations are greatly increased by grapefruit juice." Eur J Clin Pharmacol 68 (2012): 979-86
Conditions
Conditions in which Ketamine Hydrochloride needs care, as documented in this source.
Hypertension
MajorThe use of ketamine is contraindicated in patients whom a significant elevation of blood pressure would constitute a serious hazard. It is recommended to monitor cardiac function continually during a procedure in patients with hypertension or cardiac decompensation.
1 source
- "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals (2009):
Alcoholism
ModerateKetamine should be used with caution in the chronic alcoholic and the acutely alcohol-intoxicated patient.
1 source
- "Product Information. Ketalar (ketamine)." JHP Pharmaceuticals (2009):
Therapeutic duplication
Drug classes that overlap with Ketamine Hydrochloride, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Tylenol cold multi-symptom severe
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin cold cough and flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks 44d
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Sutan-dm
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Resperal-dm
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Nuedexta
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Mucinex nightshift sinus clear & cool
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Bromhist-pdx
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Supress a pediatric
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Phlemex
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Dextromethorphan/diphenhydramine/phenylephrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Dextromethorphan/pyrilamine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Acetaminophen/chlorpheniramine/dextromethorphan/pseudoephedrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin cough & cold d
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Nohist dm
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Brompheniramine/dextromethorphan/phenylephrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Triaminic softchews cough & sore throat
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Diabetic tussin night time formula
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Phlemex forte
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil cold & flu nighttime relief
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Aspirin/chlorpheniramine/dextromethorphan/phenylpropanolamine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): M-end dmx
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin peak cold daytime cold + flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Mucinex nightshift cold & flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Chlorpheniramine/dextromethorphan/pseudoephedrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin children's cough & cold long-acting
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Pediacare children's multi-symptom cold
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Donepezil/memantine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil severe cold & flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil cough
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil d cold and flu nighttime relief
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Promethazine dm
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Bupropion/dextromethorphan