Dexlansoprazole interactions
Full monograph for DexlansoprazoleCheck it against another medicine
Medicines
143 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Acalabrutinib | Major | Absorption | Coadministration with proton pump inhibitors may significantly decrease the oral bioavailability of acalabrutinib and reduce its concentrations in plasma. The… | 2 sources — open the full entry |
| Dacomitinib | Major | Absorption | Coadministration with proton pump inhibitors (PPIs) may decrease the plasma concentrations of dacomitinib. The proposed mechanism is a pH-dependent reduction… | 2 sources — open the full entry |
| Dasatinib | Major | Absorption | Nonclinical data indicate that the solubility of dasatinib is pH-dependent. Therefore, long-term suppression of gastric acid secretion by H2-receptor… | 4 sources — open the full entry |
| Erlotinib | Major | Absorption | Concurrent administration of agents that increase gastric pH such as proton pump inhibitors may decrease the oral bioavailability of erlotinib and reduce its… | 6 sources — open the full entry |
| Methotrexate | Major | Excretion | Coadministration with proton pump inhibitors (PPIs) may increase the serum concentrations of methotrexate (MTX) and its potentially active 7-hydroxy… | 7 sources — open the full entry |
| Nelfinavir | Major | Absorption | Concurrent use of proton pump inhibitors may decrease the oral bioavailability of nelfinavir and reduce its concentrations in plasma. Nelfinavir solubility may… | 2 sources — open the full entry |
| Neratinib Maleate | Major | Absorption | Coadministration with proton pump inhibitors or H2-receptor antagonists may significantly decrease the oral bioavailability of neratinib. The solubility of… | 5 sources — open the full entry |
| Pazopanib Hydrochloride | Major | Absorption | Coadministration with proton pump inhibitors or H2-receptor antagonists may significantly decrease the oral bioavailability of pazopanib and reduce its… | 7 sources — open the full entry |
| Selpercatinib | Major | Absorption | Coadministration with drugs that increase gastric pH may significantly decrease the oral bioavailability of selpercatinib and reduce its concentrations in… | 2 sources — open the full entry |
| Sofosbuvir + Velpatasvir | Major | Absorption | Coadministration of velpatasvir with proton pump inhibitors may reduce its gastrointestinal absorption. Velpatasvir exhibits pH-dependent solubility, with…2 documented mechanisms | 4 sources — open the full entry |
| Sotorasib | Major | Absorption | Coadministration with drugs that increase gastric pH may significantly decrease the oral bioavailability of sotorasib and reduce its concentrations in plasma. | 2 sources — open the full entry |
| Tacrolimus MonohydrateOralTopical | Major | Metabolism · Synergy | Coadministration with some proton pump inhibitors (PPIs) may significantly increase the whole blood concentrations of tacrolimus, particularly in patients with… | 25 sources — open the full entry |
| Abametapir | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Amikacin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Amphotericin B | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Ampicillin Sodium | Moderate | Absorption | Because lansoprazole increases gastric pH, it theoretically could decrease absorption of drugs like ampicillin which require an acidic environment. | 8 sources — open the full entry |
| Atenolol + Chlorthalidone | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Azilsartan Medoxomil + Chlorthalidone | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Betamethasone + Clotrimazole + Gentamicin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Betamethasone + Neomycin Sulphate (Ophthalmic) | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazide | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Bumetanide | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Candesartan Cilexetil + Hydrochlorothiazide | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Carbonyl Iron + Folic Acid | Moderate | Absorption | The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent… | 12 sources — open the full entry |
| Carbonyl Iron + Folic Acid + Zinc Sulfate | Moderate | Absorption | The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent… | 12 sources — open the full entry |
| Carbonyl Iron + Folic Acid + Zinc Sulfate + Vitamin B Complex + Vitamin C | Moderate | Absorption | The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent… | 12 sources — open the full entry |
| Carboplatin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Cefditoren | Moderate | Absorption | Coadministration with H2-receptor antagonists or other agents that reduce stomach acid (e.g., proton pump inhibitors) may decrease the oral absorption and… | 2 sources — open the full entry |
| Cefpodoxime Proxetil | Moderate | Absorption | The coadministration with H2-receptor antagonists, proton pump inhibitors, or other agents that can increase gastric pH may reduce the oral bioavailability of… | 4 sources — open the full entry |
| Cefpodoxime Proxetil + Clavulanic Acid | Moderate | Absorption | The coadministration with H2-receptor antagonists, proton pump inhibitors, or other agents that can increase gastric pH may reduce the oral bioavailability of… | 4 sources — open the full entry |
| Cefuroxime Axetil | Moderate | Absorption | The coadministration with H2-receptor antagonists, proton pump inhibitors, or other agents that can increase gastric pH may reduce the oral bioavailability of… | 4 sources — open the full entry |
| Cefuroxime Axetil + Clavulanic Acid | Moderate | Absorption | The coadministration with H2-receptor antagonists, proton pump inhibitors, or other agents that can increase gastric pH may reduce the oral bioavailability of… | 4 sources — open the full entry |
| Ceritinib | Moderate | Absorption | Drugs that alter the pH of the upper gastrointestinal tract may affect the solubility of ceritinib and reduce its bioavailability. The interaction has not been… | 2 sources — open the full entry |
| Cetuximab | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Chlorthalidone | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Framycetin + Esculin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Cinchocaine + Hydrocortisone + Neomycin + Esculin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Cisplatin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Clarithromycin | Moderate | Metabolism | Coadministration with clarithromycin may increase the plasma concentrations of lansoprazole. The proposed mechanism is clarithromycin inhibition of intestinal… | 4 sources — open the full entry |
| Clobetasol Propionate + Neomycin Sulphate + Nystatin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Cyclosporine (Oral) | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Dabigatran Etexilate Mesylate | Moderate | Synergy | Patients with gastrointestinal conditions may have an increased risk of gastrointestinal bleeding during concomitant treatment with dabigatran etexilate and… | 4 sources — open the full entry |
| Dexamethasone + Neomycin + Glacial Acetic Acid | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Dexamethasone + Neomycin Sulphate + Polymyxin B Sulphate | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Dexamethasone + Tobramycin | Moderate | Synergy | Chronic use of proton pump inhibitors (PPIs) may induce hypomagnesemia, and the risk may be increased during concomitant use of diuretics or other agents that… | 3 sources — open the full entry |
| Digoxin | Moderate | Absorption | Proton pump inhibitors may increase the bioavailability of digoxin. The mechanism may involve a pH-dependent increase in gastrointestinal absorption of digoxin… | 13 sources — open the full entry |
| Esomeprazole + Amoxicillin + Clarithromycin | Moderate | Metabolism | Coadministration with clarithromycin may increase the plasma concentrations of lansoprazole. The proposed mechanism is clarithromycin inhibition of intestinal… | 4 sources — open the full entry |
| Ethinyl Estradiol + Levonorgestrel + Ferrous Fumarate | Moderate | Absorption | The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent… | 12 sources — open the full entry |
| Ferric Maltol | Moderate | Absorption | Inhibitors of the proton pump (PPIs or potassium-competitive acid blockers [PCABs]) may impair the gastrointestinal absorption of nonheme iron, a process that… | 12 sources — open the full entry |
| Ferrous Fumarate + Folic acid | Moderate | Absorption | The profound hypochlorhydria induced by proton pump inhibitors (PPIs) may impair the gastrointestinal absorption of nonheme iron, a process that is dependent… | 12 sources — open the full entry |
Conditions
Conditions in which Dexlansoprazole needs care, as documented in this source.
Clostridium Infections
MajorPublished observational studies suggest that proton pump inhibitor (PPI) use may be associated with an increased risk of Clostridium difficile-associated diarrhea (CDAD), especially in hospitalized patients. This diagnosis should be considered for diarrhea that does not improve. It is recommended that patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. Close monitoring is recommended in patients with diarrhea and in those taking antibacterial agents as CDAD has been reported with the use of nearly all these agents. Treatment with antibacterial agents alters the normal flora of the colon, leading to overgrowth of C. difficile. C. difficile produces toxins A and B, which contribute to the development of CDAD. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.
8 sources
- "Product Information. PriLOSEC (omeprazole)." Merck & Co., Inc (2022):
- "Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc (2001):
- "Product Information. Aciphex (rabeprazole)." Janssen Pharmaceuticals (2001):
- "Product Information. Protonix (pantoprazole)." Wyeth-Ayerst Laboratories (2001):
- "Product Information. Protonix IV (pantoprazole)." Wyeth-Ayerst Laboratories
- "Product Information. Kapidex (dexlansoprazole)." Takeda Pharmaceuticals America (2009):
- "Product Information. NexIUM I.V. (esomeprazole)." Astra-Zeneca Pharmaceuticals (2014):
- "Product Information. Esomeprazole Strontium (esomeprazole)." Amneal Pharmaceuticals (2014):
Fractures, Bone
ModerateVarious published observational studies have reported that PPI therapy may be associated with an increased risk for osteoporosis related fractures of the hip, wrist or spine. The risk was increased in patients who received high doses (multiple daily doses), and long term treatment (a year or longer). Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the condition being treated. Caution should be used in patients at risk for osteoporosis related fractures and should be managed according to established treatment guidelines.
6 sources
- "Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc (2001):
- "Product Information. Aciphex (rabeprazole)." Janssen Pharmaceuticals (2001):
- "Product Information. Protonix (pantoprazole)." Wyeth-Ayerst Laboratories (2001):
- "Product Information. Nexium (esomeprazole)." Astra-Zeneca Pharmaceuticals (2001):
- "Product Information. Omeprazole (omeprazole)." Mylan Pharmaceuticals Inc (2003):
- "Product Information. Kapidex (dexlansoprazole)." Takeda Pharmaceuticals America (2009):
Hypomagnesemia 1, Intestinal
ModerateSymptomatic and asymptomatic hypomagnesemia has been reported rarely in patients treated with PPIs for at least 3 months, in most cases after a year of therapy. Serious adverse events can include tetany, seizures, and arrhythmias. Caution should be used in patients prone to magnesium imbalances such as patients taking other medications that can cause hypomagnesemia (e.g., diuretics). Regular monitoring is recommended.
6 sources
- "Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc (2001):
- "Product Information. Aciphex (rabeprazole)." Janssen Pharmaceuticals (2001):
- "Product Information. Protonix (pantoprazole)." Wyeth-Ayerst Laboratories (2001):
- "Product Information. Nexium (esomeprazole)." Astra-Zeneca Pharmaceuticals (2001):
- "Product Information. Omeprazole (omeprazole)." Mylan Pharmaceuticals Inc (2003):
- "Product Information. Kapidex (dexlansoprazole)." Takeda Pharmaceuticals America (2009):
Liver Diseases
ModerateDexlansoprazole is primarily metabolized by the liver. No dosage adjustment is necessary for patients with mild hepatic impairment (Child Pugh Class A). A dose of 30 mg should be considered for patients with moderate hepatic impairment (Child Pugh Class B). No studies have been conducted in patients with severe hepatic impairment (Child Pugh Class C).
1 source
- "Product Information. Kapidex (dexlansoprazole)." Takeda Pharmaceuticals America (2009):
Therapeutic duplication
Drug classes that overlap with Dexlansoprazole, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
acid suppressant agents
The recommended maximum number of medicines in the 'acid suppressant agents' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'acid suppressant agents' category.
Example product in the source data (US market): Esomeprazole/naproxen
acid suppressant agents
The recommended maximum number of medicines in the 'acid suppressant agents' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'acid suppressant agents' category.
Example product in the source data (US market): Prevpac
acid suppressant agents
The recommended maximum number of medicines in the 'acid suppressant agents' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'acid suppressant agents' category.
Example product in the source data (US market): Amoxicillin/clarithromycin/omeprazole
acid suppressant agents
The recommended maximum number of medicines in the 'acid suppressant agents' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'acid suppressant agents' category.
Example product in the source data (US market): Voquezna triple pak
acid suppressant agents
The recommended maximum number of medicines in the 'acid suppressant agents' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'acid suppressant agents' category.
Example product in the source data (US market): Aspirin/omeprazole