Tretinoin (Topical) interactions

Checked as Tretinoin (topical) in this data source.

Full monograph for Tretinoin (Topical)Check it against another medicine

Medicines

6 documented

Severity

Mechanism

Medicines documented to interact with Tretinoin (Topical), worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Adapalene + Benzoyl peroxide	Moderate	Others	Concomitant use of retinoids and keratolytic or astringent topicals may result in excessive irritation and/or drying.	2 sources — open the full entry
Benzoyl Peroxide	Moderate	Others	Concomitant use of retinoids and keratolytic or astringent topicals may result in excessive irritation and/or drying.	2 sources — open the full entry
Clascoterone	Moderate	Synergy	Clascoterone applied topically can cause local irritation such as erythema or redness, pruritus, scaling, and dryness. Concomitant use with other potentially…	1 sources — open the full entry
Clindamycin + Benzoyl peroxide	Moderate	Others	Concomitant use of retinoids and keratolytic or astringent topicals may result in excessive irritation and/or drying.	2 sources — open the full entry
IsotretinoinOral Topical	Moderate	Synergy	Concomitant use of isotretinoin with topical exfoliative or keratolytic anti-acne agents may increase local skin irritation.	2 sources — open the full entry
Methoxsalen	Moderate	Synergy	Concomitant use of methoxsalen with other known photosensitizing agents may increase the risk of photosensitivity reactions. These agents include anthralin…	7 sources — open the full entry

Conditions

Conditions in which Tretinoin (Topical) needs care, as documented in this source.

Eczema
Major
Topical retinoids may cause severe irritation on eczematous skin. Therapy with topical retinoids should be avoided on abraded or eczematous skin.
3 sources
1. "Product Information. Retin-A (tretinoin)." Ortho McNeil Pharmaceutical (2001):
2. "Product Information. Differin (adapalene topical)." Galderma Laboratories Inc (2001):
3. "Product Information. Tazorac (tazarotene topical)." Allergan Inc (2001):
Sunburn
Moderate
Retinoid-like products can cause extreme irritation when applied to sunburned skin. Patients with sunburn should be cautioned not to use retinoid-like acne products until fully recovered, and to avoid prolonged exposure to sunlight (including sunlamps) and use sunscreen/protective clothing during treatment with these products.
4 sources
1. Rosenbluth M "Adverse reaction to retin-A." J Am Dent Assoc 119 (1989): 346
2. "Product Information. Retin-A (tretinoin)." Ortho McNeil Pharmaceutical (2001):
3. "Product Information. Differin (adapalene topical)." Galderma Laboratories Inc (2001):
4. "Product Information. Tazorac (tazarotene topical)." Allergan Inc (2001):