Risdiplam interactions

Full monograph for Risdiplam Check it against another medicine

Medicines

12 documented

Severity

Mechanism

Medicines documented to interact with Risdiplam, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Chloroquine Phosphate	Moderate	Synergy	Theoretical concerns exist that oculotoxic effects of risdiplam, observed in monkeys, may be additive with those of other drugs that are associated with…	15 sources — open the full entry
Empagliflozin + Metformin Hydrochloride	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry
Fexofenadine Hydrochloride	Moderate	Excretion	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	3 sources — open the full entry
Glimepiride + Metformin	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry
Glipizide + Metformin Hydrochloride	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry
Hydroxychloroquine Sulphate	Moderate	Synergy	Theoretical concerns exist that oculotoxic effects of risdiplam, observed in monkeys, may be additive with those of other drugs that are associated with…	15 sources — open the full entry
Linagliptin + Metformin Hydrochloride	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry
Metformin Hydrochloride	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry
Pioglitazone + Metformin Hydrochloride	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry
Sitagliptin + Metformin Hydrochloride	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry
Trifluridine + Tipiracil	Moderate	Excretion · Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…2 documented mechanisms	5 sources — open the full entry
Vildagliptin + Metformin Hydrochloride	Moderate	Metabolism	Coadministration with risdiplam may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of multidrug and toxin…	2 sources — open the full entry

Conditions

Conditions in which Risdiplam needs care, as documented in this source.

Liver Diseases
Moderate
The pharmacokinetics and safety of risdiplam in patients with severe hepatic impairment (Child-Pugh class C) have not been studied. In patients with mild or moderate hepatic impairment, clinically meaningful differences have not been observed.
2 sources
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Evrysdi (risdiplam)." Genentech (2020):