Pralidoxime Chloride interactions
Checked as Pralidoxime in this data source.
Full monograph for Pralidoxime ChlorideCheck it against another medicine
Medicines
2 documented
Mechanism
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Suxamethonium Chloride | Moderate | Antagonism | Oximes used in organophosphorous poisoning such as pralidoxime or obidoxime may antagonize the neuromuscular blocking effects of succinylcholine and… | 3 sources — open the full entry |
| Atropine Sulfate (Injection) | Minor | Synergy | Pralidoxime and other drugs within the family of compounds called oximes, such as obidoxime, may potentiate the pharmacologic effects of atropine. Signs of… | 1 sources — open the full entry |
Conditions
Conditions in which Pralidoxime Chloride needs care, as documented in this source.
Myasthenia Gravis
MajorPralidoxime reactivates cholinesterase activity resulting in reduced levels of acetylcholine and increased neuromuscular junction activity. Treatment of organophosphate poisoning in patients myasthenia gravis with pralidoxime can precipitate a myasthenic crisis.
1 source
- "Product Information. Protopam Chloride (pralidoxime)." Baxter Healthcare Corporation (2001):
Kidney Diseases
ModeratePralidoxime is eliminated by the kidney. Approximately 80% to 90% of pralidoxime is excreted in the urine as unchanged drug. The serum concentration of pralidoxime is increased in patients with renal impairment. Therapy with pralidoxime should be administered cautiously and dosages reduced in patients with compromised renal function. Clinical monitoring of renal function and muscular activity is recommended.
1 source
- "Product Information. Protopam Chloride (pralidoxime)." Baxter Healthcare Corporation (2001):