Memantine + Donepezil interactions
Checked as Memantine + Donepezil in this data source.
Full monograph for Memantine + DonepezilCheck it against another medicine
Medicines
613 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Bupropion Hydrochloridevia Memantine, Donepezil | Major | Metabolism · Unknown | The use of bupropion is associated with a dose-related risk of seizures. The risk may be further increased when coadministered with other agents that can…2 documented mechanisms | 23 sources — open the full entry |
| Dextromethorphan + Bupropionvia Memantine, Donepezil | Major | Metabolism · Others · Unknown | The use of bupropion is associated with a dose-related risk of seizures. The risk may be further increased when coadministered with other agents that can…3 documented mechanisms | 28 sources — open the full entry |
| Iohexolvia Donepezil | Major | Synergy | Intrathecal administration of iodinated contrast media may induce seizures. Although clinical data are generally lacking, there may be a theoretical risk of… | 5 sources — open the full entry |
| Iopamidolvia Donepezil | Major | Synergy | Intrathecal administration of iodinated contrast media may induce seizures. Although clinical data are generally lacking, there may be a theoretical risk of… | 5 sources — open the full entry |
| Paracetamol + Tramadol Hydrochloridevia Memantine, Donepezil | Major | Synergy · Unknown | The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin…4 documented mechanisms | 8 sources — open the full entry |
| Tramadol Hydrochloridevia Memantine, Donepezil | Major | Synergy · Unknown | The risk of seizures may be increased during coadministration of tramadol with any substance that can reduce the seizure threshold, such as selective serotonin…2 documented mechanisms | 8 sources — open the full entry |
| Abametapirvia Donepezil | Moderate | Metabolism | Based on in vitro inhibition data, a single topical application of abametapir lotion may increase plasma concentrations of drugs that are substrates of CYP450… | 1 sources — open the full entry |
| Alectinibvia Donepezil | Moderate | Synergy | Coadministration of alectinib with other agents that can slow the heart rate may increase the risk of bradycardia. | 4 sources — open the full entry |
| Alfuzosin Hydrochloridevia Memantine, Donepezil | Moderate | Synergy · Unknown | Acetylcholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes, which occasionally manifest as bradycardia or heart…2 documented mechanisms | 6 sources — open the full entry |
| Amiodarone Hydrochloridevia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Amitriptyline Hydrochloridevia Memantine, Donepezil | Moderate | Antagonism · Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 25 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxidevia Memantine, Donepezil | Moderate | Antagonism · Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 25 sources — open the full entry |
| Amlodipine Besilatevia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Amlodipine Besilate + Atenololvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…4 documented mechanisms | 6 sources — open the full entry |
| Amlodipine Besilate + Atorvastatinvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…4 documented mechanisms | 6 sources — open the full entry |
| Amlodipine Besilate + Benazepril Hydrochloridevia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Amlodipine Besilate + Olmesartan Medoxomilvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Amlodipine Besilate + Telmisartanvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…4 documented mechanisms | 6 sources — open the full entry |
| Amlodipine Besilate + Valsartanvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…4 documented mechanisms | 6 sources — open the full entry |
| Apalutamidevia Donepezil | Moderate | Metabolism | Coadministration with drugs that are inducers of the CYP450 3A4 and/or 2D6 enzymatic pathways may decrease the plasma concentrations of donepezil. The… | 8 sources — open the full entry |
| Aripiprazolevia Memantine, Donepezil | Moderate | Antagonism · Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 25 sources — open the full entry |
| Arsenic Trioxidevia Donepezil | Moderate | Synergy | Acetylcholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes, which occasionally manifest as bradycardia or heart… | 6 sources — open the full entry |
| Artemether + Lumefantrinevia Donepezil | Moderate | Metabolism | Coadministration with lumefantrine may increase the plasma concentrations of drugs that are substrates of the CYP450 2D6 isoenzyme. In vitro, lumefantrine…2 documented mechanisms | 5 sources — open the full entry |
| Asciminibvia Donepezil | Moderate | Others | It is uncertain whether asciminib causes clinically significant prolongation of the QT interval of the electrocardiogram. | 2 sources — open the full entry |
| Asenapine Maleatevia Memantine, Donepezil | Moderate | Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 25 sources — open the full entry |
| Atenololvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Atenolol + Chlorthalidonevia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Atomoxetine Hydrochloridevia Memantine, Donepezil | Moderate | Synergy · Unknown | Acetylcholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes, which occasionally manifest as bradycardia or heart…2 documented mechanisms | 6 sources — open the full entry |
| Atropine Sulfate (Injection)via Memantine, Donepezil | Moderate | Antagonism · Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 28 sources — open the full entry |
| Atropine Sulfate (Ophthalmic)via Donepezil | Moderate | Antagonism | Acetylcholinesterase inhibitors (e.g., donepezil, galantamine, physostigmine, rivastigmine, tacrine) may antagonize the effects of anticholinergic agents and… | 9 sources — open the full entry |
| Azithromycin DihydratebaseOphthalmicvia Donepezil | Moderate | Synergy | Acetylcholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes, which occasionally manifest as bradycardia or heart… | 6 sources — open the full entry |
| Beclometasone + Formoterol + Glycopyrroniumvia Memantine, Donepezil | Moderate | Antagonism · Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 28 sources — open the full entry |
| Betaxolol Hydrochloridevia Donepezil | Moderate | Synergy | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive… | 6 sources — open the full entry |
| Bethanechol Chloridevia Donepezil | Moderate | Synergy | A synergistic effect may be expected when acetylcholinesterase inhibitors are administered concurrently with other cholinesterase inhibitors or cholinergic… | 3 sources — open the full entry |
| Bimatoprost + Timololvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…4 documented mechanisms | 6 sources — open the full entry |
| Bisoprolol Fumaratevia Donepezil | Moderate | Synergy | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive… | 6 sources — open the full entry |
| Bisoprolol Fumarate + Amlodipine Besilatevia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…3 documented mechanisms | 6 sources — open the full entry |
| Bisoprolol Fumarate + Hydrochlorothiazidevia Memantine, Donepezil | Moderate | Excretion · Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…3 documented mechanisms | 11 sources — open the full entry |
| Bosentan Monohydratevia Donepezil | Moderate | Metabolism | Coadministration with bosentan may decrease the plasma concentrations of drugs that are substrates of the CYP450 2C9 and/or 3A4 isoenzymes. The mechanism is… | 5 sources — open the full entry |
| Brexpiprazolevia Memantine, Donepezil | Moderate | Antagonism · Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…2 documented mechanisms | 25 sources — open the full entry |
| Brigatinibvia Donepezil | Moderate | Synergy | Coadministration of brigatinib with other agents that can also slow the heart rate may potentiate the risk of severe bradycardia. | 2 sources — open the full entry |
| Brimonidine Tartrate + Timolol Maleatevia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…4 documented mechanisms | 6 sources — open the full entry |
| Brinzolamide + Timololvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Budesonide + Glycopyrronium Bromide + Formoterol Fumaratevia Memantine, Donepezil | Moderate | Antagonism · Synergy · Unknown | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic…3 documented mechanisms | 28 sources — open the full entry |
| Cabozantinibvia Donepezil | Moderate | Synergy | Acetylcholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes, which occasionally manifest as bradycardia or heart… | 6 sources — open the full entry |
| Calcium Dobesilate + Lidocaine + Dexamethasonevia Memantine, Donepezil | Moderate | Metabolism · Unknown | Coadministration with drugs that are inducers of the CYP450 3A4 and/or 2D6 enzymatic pathways may decrease the plasma concentrations of donepezil. The…4 documented mechanisms | 8 sources — open the full entry |
| Carbamazepinevia Memantine, Donepezil | Moderate | Antagonism · Unknown | Due to opposing effects, agents that possess anticholinergic activity (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal…2 documented mechanisms | 6 sources — open the full entry |
| Cariprazinevia Memantine | Moderate | Synergy | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic… | 19 sources — open the full entry |
| Carvedilolvia Memantine, Donepezil | Moderate | Synergy · Unknown | Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive…2 documented mechanisms | 6 sources — open the full entry |
| Cenobamatevia Donepezil | Moderate | Metabolism | Coadministration with drugs that are inducers of the CYP450 3A4 and/or 2D6 enzymatic pathways may decrease the plasma concentrations of donepezil. The… | 8 sources — open the full entry |
Conditions
Conditions in which Memantine + Donepezil needs care, as documented in this source.
Bradycardia
MajorDue to their pharmacological action, cholinesterase inhibitors can have a vagotonic effect on the sinoatrial and atrioventricular nodes producing bradycardia or heart block. Therapy with cholinesterase inhibitors should be administered cautiously in patients with preexisting bradycardia or underlying cardiac conduction abnormalities. Syncopal episodes have been reported in patients with and without cardiac abnormalities. Atropine may be used to reverse bradycardia produced by cholinesterase inhibitors.
13 sources
- Wilcock GK, Surmon D, Forsyth D, Morgan R "Cholinergic side-effects of tetrahydroaminoacridine." Lancet 2 (1988): 1305
- "Product Information. Cognex (tacrine)." Parke-Davis (2001):
- Baldessarini RJ, Gelenberg AJ "Using physostigmine safely." Am J Psychiatry 136 (1979): 1608-9
- Janowsky DS, Risch SC, Huey LY, Kennedy B, Ziegler M "Effects of physostigmine on pulse, blood pressure, and serum epinephrine levels." Am J Psychiatry 142 (1985): 738-40
- Dysken MW, Janowsky DS "Dose-related physostigmine-induced ventricular arrhythmia: case report." J Clin Psychiatry 46 (1985): 446-7
- "Product Information. Phospholine Iodide (echothiophate iodide ophthalmic)." Wyeth-Ayerst Laboratories
- "Product Information. Mestinon (pyridostigmine)." ICN Pharmaceuticals Inc (2001):
- "Product Information. Prostigman (neostigmine)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
Show all 13 sourcesShow fewer sources
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
- "Product Information. Humorsol Ocumeter (demecarium bromide ophthalmic)." Merck & Co., Inc
- "Product Information. Eserine Sulfate Ophthalmic (PHYSostigmine ophthalmic)." Ciba Vision Ophthalmics
- "Product Information. Exelon (rivastigmine)." Novartis Pharmaceuticals (2001):
- "Product Information. Reminyl (galantamine)." Janssen Pharmaceuticals (2001):
Bronchial Spasm
MajorCholinesterase inhibitors inhibit the hydrolysis of acetylcholine. The enhanced effect of acetylcholine produces constriction of the bronchi, increased bronchial secretions, and bronchospasm. Therapy with cholinesterase inhibitors should be administered cautiously in patients with respiratory dysfunction, history of asthma or obstructive pulmonary disease. Monitoring respiratory function during dosage initiation and adjustment is recommended. Use of atropine along with discontinuation of the cholinesterase inhibitor may be required for serious respiratory distress. Neostigmine may produce more severe muscarinic side effects than does pyridostigmine and ambenonium. However, the duration of action is longest for ambenonium and shortest for edrophonium. Echothiophate iodide ophthalmic may be systemically absorbed and cautious use is recommended in these patients.
10 sources
- Wilcock GK, Surmon D, Forsyth D, Morgan R "Cholinergic side-effects of tetrahydroaminoacridine." Lancet 2 (1988): 1305
- "Product Information. Cognex (tacrine)." Parke-Davis (2001):
- "Product Information. Phospholine Iodide (echothiophate iodide ophthalmic)." Wyeth-Ayerst Laboratories
- "Product Information. Mestinon (pyridostigmine)." ICN Pharmaceuticals Inc (2001):
- "Product Information. Prostigman (neostigmine)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
- "Product Information. Humorsol Ocumeter (demecarium bromide ophthalmic)." Merck & Co., Inc
- "Product Information. Eserine Sulfate Ophthalmic (PHYSostigmine ophthalmic)." Ciba Vision Ophthalmics
Show all 10 sourcesShow fewer sources
- "Product Information. Exelon (rivastigmine)." Novartis Pharmaceuticals (2001):
- "Product Information. Reminyl (galantamine)." Janssen Pharmaceuticals (2001):
Coronary Artery Disease
MajorThe use of cholinesterase inhibitors has been associated with a constriction of coronary arteries. Therapy with cholinesterase inhibitors should be administered cautiously in patients with coronary artery disease.
8 sources
- "Product Information. Cognex (tacrine)." Parke-Davis (2001):
- Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255
- "Product Information. Phospholine Iodide (echothiophate iodide ophthalmic)." Wyeth-Ayerst Laboratories
- "Product Information. Mestinon (pyridostigmine)." ICN Pharmaceuticals Inc (2001):
- "Product Information. Prostigman (neostigmine)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
- "Product Information. Humorsol Ocumeter (demecarium bromide ophthalmic)." Merck & Co., Inc
- "Product Information. Eserine Sulfate Ophthalmic (PHYSostigmine ophthalmic)." Ciba Vision Ophthalmics
Parkinsonian Disorders
MajorCholinesterase inhibitors should be used with caution in patients with parkinsonism. Some of these drugs might be contraindicated in these patients (refer to specific prescribing information). Symptoms of Parkinson's disease may be exacerbated with the increase in cholinergic activity. Caregivers and patients should be advised.
8 sources
- "Product Information. Cognex (tacrine)." Parke-Davis (2001):
- el-Yousef MK, Janowsky D, Davis JM, Sekerke HJ "Reversal of antiparkinsonian drug toxicity by physostigmine: a controlled study." Am J Psychiatry 130 (1973): 141-5
- Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255
- "Product Information. Phospholine Iodide (echothiophate iodide ophthalmic)." Wyeth-Ayerst Laboratories
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
- "Product Information. Humorsol Ocumeter (demecarium bromide ophthalmic)." Merck & Co., Inc
- "Product Information. Eserine Sulfate Ophthalmic (PHYSostigmine ophthalmic)." Ciba Vision Ophthalmics
- "Product Information. Exelon (rivastigmine)." Novartis Pharmaceuticals (2001):
Peptic Ulcer
MajorThe use of cholinesterase inhibitors is associated with an increase in gastric acid secretion and gastric contractions. Therapy with cholinesterase inhibitors should be administered cautiously in patients with peptic ulcer disease.
9 sources
- "Product Information. Cognex (tacrine)." Parke-Davis (2001):
- "Product Information. Phospholine Iodide (echothiophate iodide ophthalmic)." Wyeth-Ayerst Laboratories
- "Product Information. Mestinon (pyridostigmine)." ICN Pharmaceuticals Inc (2001):
- "Product Information. Prostigman (neostigmine)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
- "Product Information. Humorsol Ocumeter (demecarium bromide ophthalmic)." Merck & Co., Inc
- "Product Information. Eserine Sulfate Ophthalmic (PHYSostigmine ophthalmic)." Ciba Vision Ophthalmics
- "Product Information. Exelon (rivastigmine)." Novartis Pharmaceuticals (2001):
Show all 9 sourcesShow fewer sources
- "Product Information. Reminyl (galantamine)." Janssen Pharmaceuticals (2001):
Seizures
MajorCholinesterase inhibitors have been associated with convulsions and tremor. Therapy with cholinesterase inhibitors should be administered cautiously in patients with seizure disorders.
9 sources
- "Product Information. Cognex (tacrine)." Parke-Davis (2001):
- Stewart GO "Convulsions after physostigmine." Anaesth Intensive Care 7 (1979): 283
- "Product Information. Phospholine Iodide (echothiophate iodide ophthalmic)." Wyeth-Ayerst Laboratories
- "Product Information. Mestinon (pyridostigmine)." ICN Pharmaceuticals Inc (2001):
- "Product Information. Prostigman (neostigmine)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
- "Product Information. Humorsol Ocumeter (demecarium bromide ophthalmic)." Merck & Co., Inc
- "Product Information. Eserine Sulfate Ophthalmic (PHYSostigmine ophthalmic)." Ciba Vision Ophthalmics
Show all 9 sourcesShow fewer sources
- "Product Information. Exelon (rivastigmine)." Novartis Pharmaceuticals (2001):
Hepatic Insufficiency
ModerateMemantine should be used with caution in patients with severe hepatic impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate hepatic impairment.
1 source
- "Product Information. Namenda (memantine)." Forest Pharmaceuticals (2003):
Hyperthyroidism
ModerateMany of the manifestations of hyperthyroidism may be exacerbated by increased levels of acetylcholine produced by cholinesterase inhibitors. Therapy with cholinesterase inhibitors should be administered cautiously to patients with hyperthyroidism. Monitoring of thyroid levels is recommended.
5 sources
- "Product Information. Cognex (tacrine)." Parke-Davis (2001):
- Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255
- "Product Information. Mestinon (pyridostigmine)." ICN Pharmaceuticals Inc (2001):
- "Product Information. Prostigman (neostigmine)." ICN Pharmaceuticals Inc, Cost Mesa, CA.
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
Kidney Diseases
ModerateMemantine renal clearance involves active tubular secretion moderated by pH dependent tubular reabsorption and conditions that raise urine pH may increase the plasma levels of memantine. Therapy with memantine should be used cautiously in patients with conditions that raise urine pH, such as renal tubular acidosis or severe infections of the urinary tract. Additionally, memantine should be used with caution in patients with severe renal impairment and a dosage reduction is recommended. No dosage adjustment is needed in patients with mild or moderate renal impairment.
1 source
- "Product Information. Namenda (memantine)." Forest Pharmaceuticals (2003):
Liver Diseases
ModerateDonepezil is extensively metabolized by the liver (CYP450-2D6/3A4) to two active and various minor forms. The clearance of donepezil was decreased 20% in patients with stable alcoholic cirrhosis compared to healthy patients. Care should be exercised when using donepezil in patients with liver disease.
2 sources
- "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals (2001):
- Rogers SL, Friedhoff LT "The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicentre, randomized, double-blind, placebo-controlled trial." Dementia 7 (1996): 293-303
Therapeutic duplication
Drug classes that overlap with Memantine + Donepezil, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
cholinergics
The recommended maximum number of medicines in the 'cholinergics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'cholinergics' category.
Example product in the source data (US market): Glycopyrrolate/neostigmine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Bupropion/dextromethorphan
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Tylenol cold multi-symptom severe
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin cold cough and flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks 44d
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Sutan-dm
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Resperal-dm
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Nuedexta
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Mucinex nightshift sinus clear & cool
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Bromhist-pdx
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Supress a pediatric
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Phlemex
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Dextromethorphan/diphenhydramine/phenylephrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Dextromethorphan/pyrilamine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin cough & cold d
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Acetaminophen/chlorpheniramine/dextromethorphan/pseudoephedrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Nohist dm
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Brompheniramine/dextromethorphan/phenylephrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Triaminic softchews cough & sore throat
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Diabetic tussin night time formula
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Phlemex forte
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil cold & flu nighttime relief
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): M-end dmx
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin peak cold daytime cold + flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Aspirin/chlorpheniramine/dextromethorphan/phenylpropanolamine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Mucinex nightshift cold & flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Chlorpheniramine/dextromethorphan/pseudoephedrine
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Robitussin children's cough & cold long-acting
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Pediacare children's multi-symptom cold
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil severe cold & flu
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil cough
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Vicks nyquil d cold and flu nighttime relief
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Promethazine dm