Diphenhydramine + Dextromethorphan + Levomenthol interactions
Checked as Diphenhydramine + Dextromethorphan in this data source.
Full monograph for Diphenhydramine + Dextromethorphan + LevomentholCheck it against another medicine
Medicines
338 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Almotriptanvia Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1… | 99 sources — open the full entry |
| Amitriptyline Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Amitriptyline Hydrochloride + Chlordiazepoxidevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…4 documented mechanisms | 162 sources — open the full entry |
| Brexpiprazolevia Dextromethorphan, Diphenhydramine | Major | Metabolism · Synergy | Coadministration with inhibitors of CYP450 3A4 and/or 2D6 may significantly increase the plasma concentrations of brexpiprazole, which is metabolized by these…2 documented mechanisms | 49 sources — open the full entry |
| Citalopram Hydrobromidevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 178 sources — open the full entry |
| Clobetasol Propionate + Ofloxacin + Ornidazole + Terbinafinevia Dextromethorphan | Major | Metabolism · Unknown | Coadministration with potent CYP450 2D6 inhibitors (e.g., quinidine, terbinafine) may significantly increase the plasma concentrations of dextromethorphan in…2 documented mechanisms | 46 sources — open the full entry |
| Clomipramine Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Cyclobenzaprine Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Desvenlafaxine Succinatevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 178 sources — open the full entry |
| Doxepin (Oral)via Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Doxepin (Topical)via Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Duloxetine Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Metabolism · Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 137 sources — open the full entry |
| Escitalopram Oxalatevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 178 sources — open the full entry |
| Fentanyl Citratevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 143 sources — open the full entry |
| Fluoxetine Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Metabolism · Synergy | Coadministration with potent CYP450 2D6 inhibitors (e.g., quinidine, terbinafine) may significantly increase the plasma concentrations of dextromethorphan in…2 documented mechanisms | 90 sources — open the full entry |
| Fluphenazine + Nortriptylinevia Diphenhydramine, Dextromethorphan | Major | Antagonism · Metabolism · Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…4 documented mechanisms | 145 sources — open the full entry |
| Fluvoxamine Maleatevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 178 sources — open the full entry |
| Granisetronvia Dextromethorphan | Major | Synergy | Concomitant use of 5-HT3 receptor antagonists with agents that possess or enhance serotonergic activity such as selective serotonin reuptake inhibitors… | 7 sources — open the full entry |
| Imipramine Hydrochloridevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Lasmiditan Hemisuccinatevia Dextromethorphan, Diphenhydramine | Major | Synergy | Coadministration of lasmiditan and serotonergic agents may increase the risk of serotonin syndrome. Lasmiditan binds to the 5-HT(1F) receptor, where it…2 documented mechanisms | 10 sources — open the full entry |
| Levomilnacipran Hydrochloridevia Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1… | 134 sources — open the full entry |
| Linezolidvia Diphenhydramine, Dextromethorphan | Major | Synergy | Coadministration of dextromethorphan with linezolid may increase the risk of serotonin syndrome, a rare but serious and potentially fatal condition thought to…2 documented mechanisms | 73 sources — open the full entry |
| Maprotiline Hydrochloridevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Milnacipran Hydrochloridevia Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1… | 134 sources — open the full entry |
| Mirtazapinevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 144 sources — open the full entry |
| Nortriptylinevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 118 sources — open the full entry |
| Ondansetronvia Dextromethorphan | Major | Synergy | Concomitant use of 5-HT3 receptor antagonists with agents that possess or enhance serotonergic activity such as selective serotonin reuptake inhibitors… | 7 sources — open the full entry |
| Palonosetronvia Dextromethorphan | Major | Synergy | Concomitant use of 5-HT3 receptor antagonists with agents that possess or enhance serotonergic activity such as selective serotonin reuptake inhibitors… | 7 sources — open the full entry |
| Paracetamol + Tramadol Hydrochloridevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 143 sources — open the full entry |
| Paroxetine Hydrochloridevia Diphenhydramine, Dextromethorphan | Major | Metabolism · Synergy | Coadministration with potent CYP450 2D6 inhibitors (e.g., quinidine, terbinafine) may significantly increase the plasma concentrations of dextromethorphan in…2 documented mechanisms | 90 sources — open the full entry |
| Pentazocinevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 143 sources — open the full entry |
| Pethidine Hydrochloridevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 143 sources — open the full entry |
| Potassium Chloridevia Diphenhydramine, Dextromethorphan | Major | Absorption · Unknown | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants…2 documented mechanisms | 15 sources — open the full entry |
| Potassium Citratevia Diphenhydramine | Major | Synergy | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants… | 15 sources — open the full entry |
| Potassium Citrate + Citric Acidvia Diphenhydramine | Major | Synergy | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants… | 15 sources — open the full entry |
| Rasagilinevia Dextromethorphan, Diphenhydramine | Major | Synergy | By inhibiting serotonin metabolism, monoamine oxidase inhibitors (MAOIs) may potentiate the pharmacologic activity of serotonergic agents such as serotonin…2 documented mechanisms | 118 sources — open the full entry |
| Remifentanil Hydrochloridevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 143 sources — open the full entry |
| Rizatriptan Benzoatevia Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1… | 99 sources — open the full entry |
| Safinamide Mesylatevia Dextromethorphan, Diphenhydramine | Major | Metabolism · Synergy | By inhibiting serotonin metabolism, monoamine oxidase inhibitors (MAOIs), including the selective MAO-B inhibitor safinamide, may potentiate the pharmacologic…2 documented mechanisms | 153 sources — open the full entry |
| Sertraline Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 178 sources — open the full entry |
| Sodium Chloride + Potassium Chloride + Sodium Acetatevia Diphenhydramine, Dextromethorphan | Major | Absorption · Unknown | Concomitant use of agents with anticholinergic properties (e.g., antihistamines, antispasmodics, neuroleptics, phenothiazines, skeletal muscle relaxants…2 documented mechanisms | 15 sources — open the full entry |
| Sumatriptanvia Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1… | 99 sources — open the full entry |
| Tamoxifen Citratevia Diphenhydramine | Major | Metabolism | Chronic coadministration of potent or moderate CYP450 2D6 inhibitors including certain antidepressants may reduce the effectiveness of tamoxifen. The proposed… | 35 sources — open the full entry |
| Tapentadol Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 144 sources — open the full entry |
| Terbinafine Hydrochloridevia Dextromethorphan | Major | Metabolism | Coadministration with potent CYP450 2D6 inhibitors (e.g., quinidine, terbinafine) may significantly increase the plasma concentrations of dextromethorphan in… | 46 sources — open the full entry |
| Topiramatevia Dextromethorphan, Diphenhydramine | Major | Synergy | Certain drugs such as carbonic anhydrase inhibitors and drugs with anticholinergic activity (e.g., antihistamines, antispasmodics, neuroleptics…2 documented mechanisms | 53 sources — open the full entry |
| Tramadol Hydrochloridevia Diphenhydramine, Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 143 sources — open the full entry |
| Venlafaxine Hydrochloridevia Dextromethorphan, Diphenhydramine | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1…2 documented mechanisms | 178 sources — open the full entry |
| Vilazodone Hydrochloridevia Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1… | 100 sources — open the full entry |
| Vortioxetine Hydrobromidevia Dextromethorphan | Major | Synergy | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1… | 134 sources — open the full entry |
Food & lifestyle
alcohol
ModerateSynergy
Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
What to do: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
4 sources
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
- "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):
alcohol
ModerateSynergy
Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system.
What to do: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
1 source
- Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12
Therapeutic duplication
Drug classes that overlap with Diphenhydramine + Dextromethorphan + Levomenthol, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
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The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Poly hist forte
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Rynex pe
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Chlorpheniramine/phenylephrine
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Vicks nyquil d cold and flu nighttime relief
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Flextra
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Phenylephrine/promethazine
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Promethazine dm
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): Pro-chlo
antihistamines
The recommended maximum number of medicines in the 'antihistamines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'antihistamines' category.
Example product in the source data (US market): All day allergy-d
nmda antagonists
The recommended maximum number of medicines in the 'NMDA antagonists' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'NMDA antagonists' category.
Example product in the source data (US market): Donepezil/memantine