Cyanocobalamin interactions
Full monograph for CyanocobalaminCheck it against another medicine
Medicines
445 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Arsenic Trioxide | Moderate | Synergy | Arsenic trioxide can cause QT interval prolongation and complete atrioventricular block. Theoretically, use of arsenic trioxide during intensive vitamin B12… | 3 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocaine | Moderate | Antagonism · Unknown | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…3 documented mechanisms | 3 sources — open the full entry |
| Chloramphenicol (Oral) | Moderate | Antagonism | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12… | 3 sources — open the full entry |
| Chloramphenicol + Lidocaine Hydrochloride | Moderate | Antagonism · Unknown | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…2 documented mechanisms | 3 sources — open the full entry |
| Dexamethasone + Chloramphenicol | Moderate | Antagonism · Unknown | Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12…2 documented mechanisms | 3 sources — open the full entry |
| Dexlansoprazole | Minor | Absorption | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of… | 5 sources — open the full entry |
| EsomeprazolebaseMUPS preparation | Minor | Absorption | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of… | 5 sources — open the full entry |
| Esomeprazole + Amoxicillin + Clarithromycin | Minor | Absorption · Unknown | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of…2 documented mechanisms | 5 sources — open the full entry |
| Famotidine | Minor | Absorption | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of… | 5 sources — open the full entry |
| Lansoprazole | Minor | Absorption | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of… | 5 sources — open the full entry |
| Lansoprazole + Amoxicillin + Clarithromycin | Minor | Absorption · Unknown | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of…2 documented mechanisms | 5 sources — open the full entry |
| Naproxen Sodium + Esomeprazole Magnesium | Minor | Absorption · Unknown | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of…2 documented mechanisms | 5 sources — open the full entry |
| OmeprazolebaseMUPS tablet | Minor | Absorption | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of… | 5 sources — open the full entry |
| Pantoprazole Sodium | Minor | Absorption | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of… | 5 sources — open the full entry |
| Potassium Chloride | Minor | Absorption | Limited data suggest that orally administered potassium chloride may decrease the gastrointestinal absorption of vitamin B12. The mechanism is believed to be a… | 1 sources — open the full entry |
| Rabeprazole + Amoxicillin + Clarithromycin | Minor | Absorption · Unknown | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of…2 documented mechanisms | 5 sources — open the full entry |
| Rabeprazole Sodium | Minor | Absorption | By reducing or suppressing gastric acid secretion, H2-receptor antagonists and proton pump inhibitors may interfere with the gastrointestinal absorption of… | 5 sources — open the full entry |
| Sodium Chloride + Potassium Chloride + Sodium Acetate | Minor | Absorption | Limited data suggest that orally administered potassium chloride may decrease the gastrointestinal absorption of vitamin B12. The mechanism is believed to be a… | 1 sources — open the full entry |
Conditions
Conditions in which Cyanocobalamin needs care, as documented in this source.
Hypokalemia
MajorHypokalemia (resulting in death) has occurred during vitamin B12 therapy as a result of increased red blood cell requirements during hematopoiesis. Clinical monitoring and correction of potassium levels prior to and during vitamin B12 therapy is necessary.
2 sources
- "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
- "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc (2001):
Optic Atrophy, Hereditary, Leber
MajorThe use of cyanocobalamin is contraindicated in patients with Leber's disease (hereditary optic nerve atrophy). Cyanocobalamin has induced severe and rapid optic nerve atrophy in patient's with early Leber's disease.
2 sources
- "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
- "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc (2001):
Kidney Diseases
ModerateCyanocobalamin products contain aluminum that may be toxic and may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and other solutions which also contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum greater than 4-5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Caution and monitoring are recommended.
2 sources
- "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
- "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc (2001):
Malabsorption Syndromes
ModerateAbsorption of vitamin B12 is decreased in malabsorption syndromes and in pernicious anemia without coadministration of intrinsic factor (IF). Cyanocobalamin is rapidly absorbed following IM or subcutaneous injections. Hydroxocobalamin (cyanocobalamin analog) functions the same a cyanocobalamin, but has induced antibody formation to the hydroxocobalamin-transcobalamin II complex. The use of cyanocobalamin may be preferred in patients with these conditions.
1 source
- "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc (2001):