Clobazam interactions

Full monograph for Clobazam Check it against another medicine

Medicines

193 of 344 shown

Severity

Mechanism

Medicines documented to interact with Clobazam, worst severity first.
Medicine	Severity	Mechanism	Effect	Sources
Clozapine	Major	Synergy	Benzodiazepines and clozapine may have additive effects on respiratory and cardiovascular function. Ataxia, excessive salivation, hypotension, collapse…	14 sources — open the full entry
Fentanyl Citrate	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Morphine Sulfate	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Nalbuphine Hydrochloride	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Oxymorphone Hydrochloride	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Paracetamol + Tramadol Hydrochloride	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Pentazocine	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Pethidine Hydrochloride	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Remifentanil Hydrochloride	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Tapentadol Hydrochloride	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Tramadol Hydrochloride	Major	Synergy	Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics…	1 sources — open the full entry
Alfuzosin Hydrochloride	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Alprazolam	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry
Amitriptyline Hydrochloride + Chlordiazepoxide	Moderate	Metabolism · Synergy	Coadministration with clobazam may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 2D6. The mechanism is decreased… 2 documented mechanisms	50 sources — open the full entry
Amlodipine Besilate	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	7 sources — open the full entry
Amlodipine Besilate + Atenolol	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	18 sources — open the full entry
Amlodipine Besilate + Atorvastatin	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	7 sources — open the full entry
Amlodipine Besilate + Benazepril Hydrochloride	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	18 sources — open the full entry
Amlodipine Besilate + Olmesartan Medoxomil	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	18 sources — open the full entry
Amlodipine Besilate + Telmisartan	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	18 sources — open the full entry
Amlodipine Besilate + Valsartan	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	7 sources — open the full entry
Articaine Hydrochloride + Epinephrine Bitartrate	Moderate	Synergy	The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants. 2 documented mechanisms	10 sources — open the full entry
Asenapine Maleate	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry
Atenolol	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Atenolol + Chlorthalidone	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	11 sources — open the full entry
Azilsartan Medoxomil	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	18 sources — open the full entry
Azilsartan Medoxomil + Chlorthalidone	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 3 documented mechanisms	18 sources — open the full entry
Baclofen	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry
Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocaine	Moderate	Metabolism · Synergy	The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants. 2 documented mechanisms	14 sources — open the full entry
Benzocaine + Butamben + Tetracaine Hydrochloride	Moderate	Synergy	The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.	7 sources — open the full entry
Betamethasone + Phenylephrine + Lignocaine	Moderate	Synergy	The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.	7 sources — open the full entry
Betaxolol Hydrochloride	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Bimatoprost + Timolol	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Bisoprolol Fumarate	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Bisoprolol Fumarate + Amlodipine Besilate	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	18 sources — open the full entry
Bisoprolol Fumarate + Hydrochlorothiazide	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	11 sources — open the full entry
Brimonidine Tartrate + Timolol Maleate	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Brinzolamide + Timolol	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Brivaracetam	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry
Bromocriptine Mesylate	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry
Bumetanide	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Bupivacaine Hydrochloride	Moderate	Synergy	The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.	7 sources — open the full entry
Bupivacaine Hydrochloride + Dextrose	Moderate	Synergy	The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.	7 sources — open the full entry
Calcium Dobesilate + Lidocaine + Dexamethasone	Moderate	Synergy	The concomitant use of local anesthetics and benzodiazepines may have additive CNS-depressant effects. Both types of drugs are CNS depressants.	7 sources — open the full entry
Candesartan Cilexetil	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	7 sources — open the full entry
Candesartan Cilexetil + Hydrochlorothiazide	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)… 2 documented mechanisms	18 sources — open the full entry
Captopril	Moderate	Synergy	Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants)…	11 sources — open the full entry
Carbamazepine	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry
Cariprazine	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry
Carisoprodol	Moderate	Synergy	Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these…	44 sources — open the full entry

Food & lifestyle

alcohol
Moderate

Synergy

Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.

What to do: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
4 sources
1. Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
2. Gilman AG, eds., Nies AS, Rall TW, Taylor P "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc. (1990):
3. "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
4. "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc (2015):

Conditions

Conditions in which Clobazam needs care, as documented in this source.

Alcoholic Intoxication
Major

The use of benzodiazepines with alcohol is not recommended. Patients with acute alcohol intoxication exhibit depressed vital signs. The central nervous system depressant effects of benzodiazepines may be additive with those of alcohol, and severe respiratory depression and death may occur. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.
14 sources
1. "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn (2002):
2. "Product Information. Valium (diazepam)." Roche Laboratories (2002):
3. "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories (2002):
4. "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories (2001):
5. "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation (2001):
6. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn (2001):
7. "Product Information. Dalmane (flurazepam)." Roche Laboratories (2001):
8. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical (2001):
Show all 14 sources Show fewer sources
1. "Product Information. Klonopin (clonazepam)." Roche Laboratories (2001):
2. "Product Information. Prosom (estazolam)." Abbott Pharmaceutical (2022):
3. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories (2001):
4. "Product Information. Doral (quazepam)." Wallace Laboratories (2001):
5. "Product Information. Versed (midazolam)." Roche Laboratories (2001):
6. "Product Information. Onfi (clobazam)." Lundbeck Inc (2011):
Substance-Related Disorders
Major

Benzodiazepines have the potential to cause dependence and abuse. Tolerance as well as physical and psychological dependence can develop, particularly after prolonged use and/or excessive dosages. However, abrupt cessation following continual use of as few as 6 weeks at therapeutic levels has occasionally precipitated withdrawal symptoms. Addiction- prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance when treated with benzodiazepines. It may be prudent to refrain from dispensing large quantities of medication to these patients. After prolonged use or if dependency is suspected, withdrawal of benzodiazepine therapy should be undertaken gradually using a dosage- tapering schedule. If withdrawal symptoms occur, temporary reinstitution of benzodiazepines may be necessary.
14 sources
1. "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn (2002):
2. "Product Information. Valium (diazepam)." Roche Laboratories (2002):
3. "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories (2002):
4. "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories (2001):
5. "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation (2001):
6. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn (2001):
7. "Product Information. Dalmane (flurazepam)." Roche Laboratories (2001):
8. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical (2001):
Show all 14 sources Show fewer sources
1. "Product Information. Klonopin (clonazepam)." Roche Laboratories (2001):
2. "Product Information. Prosom (estazolam)." Abbott Pharmaceutical (2022):
3. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories (2001):
4. "Product Information. Doral (quazepam)." Wallace Laboratories (2001):
5. "Product Information. Onfi (clobazam)." Lundbeck Inc (2011):
6. "Product Information. Byfavo (remimazolam)." Acacia Pharma, Inc (2020):
Depressive Disorder
Moderate

Benzodiazepines depress the central nervous system and may cause or exacerbate mental depression and cause suicidal behavior and ideation. Episodes of mania and hypomania have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
13 sources
1. "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn (2002):
2. "Product Information. Valium (diazepam)." Roche Laboratories (2002):
3. "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories (2002):
4. "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories (2001):
5. "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation (2001):
6. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn (2001):
7. "Product Information. Dalmane (flurazepam)." Roche Laboratories (2001):
8. "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical (2001):
Show all 13 sources Show fewer sources
1. "Product Information. Klonopin (clonazepam)." Roche Laboratories (2001):
2. "Product Information. Prosom (estazolam)." Abbott Pharmaceutical (2022):
3. "Product Information. Librium (chlordiazepoxide)." Roche Laboratories (2001):
4. "Product Information. Doral (quazepam)." Wallace Laboratories (2001):
5. "Product Information. Onfi (clobazam)." Lundbeck Inc (2011):

Therapeutic duplication

Drug classes that overlap with Clobazam, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.

benzodiazepines

The recommended maximum number of medicines in the 'benzodiazepines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'benzodiazepines' category.

Example product in the source data (US market): Librax
benzodiazepines

The recommended maximum number of medicines in the 'benzodiazepines' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'benzodiazepines' category.

Example product in the source data (US market): Limbitrol ds
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Phrenilin with caffeine and codeine
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Phrenilin
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Butabarbital/hyoscyamine/phenazopyridine
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Aspirin/butalbital/caffeine/codeine
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Micrainin
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Nodolor
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Laniroif
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Phenohytro
tranquilizers

The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'tranquilizers' category.

Example product in the source data (US market): Nonbac

Medicines

Food & lifestyle

alcohol

Conditions

Alcoholic Intoxication

Substance-Related Disorders

Depressive Disorder

Therapeutic duplication

benzodiazepines

benzodiazepines

tranquilizers

tranquilizers

tranquilizers

tranquilizers

tranquilizers

tranquilizers

tranquilizers

tranquilizers

tranquilizers