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Ceritinib + Ulipristal Acetate [For uterine fibroids]

Moderate 1 published source

This interaction is documented in this data source.

Ceritinib
Checked as Ceritinib
Ulipristal Acetate [For uterine fibroids]
Checked as Ulipristal

What is documented

  1. Others

    Moderate

    via Ceritinib and Ulipristal

    What happens

    Based on in vitro inhibition data, coadministration with ulipristal may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by ulipristal.

    What to do

    Caution is advised when ulipristal is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ulipristal is added to or withdrawn from therapy.

    1 source

    1. "Product Information. ella (ulipristal)." Afaxys Inc., Charleston, SC.

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