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Ceritinib + Lenvatinib Mesylate

Major 9 published sources

This interaction is documented in this data source.

Ceritinib
Checked as Ceritinib
Lenvatinib Mesylate
Checked as Lenvatinib

What is documented

  1. Synergy

    Major

    via Ceritinib and Lenvatinib

    What happens

    Ceritinib can cause concentration-dependent prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death.

    What to do

    Caution is recommended if ceritinib is used in combination with other drugs that can prolong the QT interval. ECG and serum electrolytes, including potassium, magnesium and calcium, should be monitored before starting ceritinib therapy and periodically during treatment.

    9 sources

    1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
    2. Cerner Multum, Inc. "Australian Product Information." O 0
    3. "Product Information. Zykadia (ceritinib)." Novartis Pharmaceuticals, East Hanover, NJ.
    4. Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
    5. "Product Information. Zykadia (ceritinib)." Novartis Pharmaceuticals, East Hanover, NJ.
    6. "Product Information. Fycompa (perampanel)." Eisai Inc, Teaneck, NJ.
    7. Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
    8. Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
    Show all 9 sources
    1. "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc, Rockville, MD.

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