Skip to content
Med Rx.

Betamethasone + Clotrimazole + Gentamicin + Losartan Potassium

Moderate 2 published sources

This interaction is documented in this data source.

Betamethasone + Clotrimazole + Gentamicin
Checked as Betamethasone + Clotrimazole + Gentamicin
Losartan Potassium
Checked as Losartan

3 documented mechanisms

This source documents more than one distinct mechanism for this pair. Each is shown with its own effect, advice and sources rather than merged into one.

  1. Mechanism 1: Antagonism · Metabolism

    Moderate

    via Betamethasone and Losartan

    What happens

    Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the natural corticosteroids (cortisone, hydrocortisone) because they have greater mineralocorticoid activity. Conversely, some calcium channel blockers such as diltiazem and verapamil may increase corticosteroid plasma levels and effects by inhibiting their clearance via CYP450 3A4 metabolism.

    What to do

    Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment.

    2 sources

    1. "Multum Information Services, Inc. Expert Review Panel"
    2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

  2. Mechanism 2: Unknown

    Listed, not described

    via Clotrimazole and Losartan

    The source lists this pair here and publishes no description, mechanism or citation for it.

    No sources recorded

  3. Mechanism 3: Unknown

    Listed, not described

    via Gentamicin and Losartan

    The source lists this pair here and publishes no description, mechanism or citation for it.

    No sources recorded

Keep checking