Benzathine Benzylpenicillin interactions
Checked as Benzylpenicillin in this data source.
Full monograph for Benzathine BenzylpenicillinCheck it against another medicine
Medicines
56 documented
| Medicine | Severity | Mechanism | Effect | Sources |
|---|---|---|---|---|
| Methotrexatematched approximately | Major | Excretion | Concomitant use of large doses of penicillins may elevate serum methotrexate concentrations. The mechanism may involve competitive inhibition of renal tubular… | 11 sources — open the full entry |
| Beclomethasone Dipropionate + Chloramphenicol + Clotrimazole + Lidocainematched approximately | Moderate | Antagonism | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol… | 4 sources — open the full entry |
| Chloramphenicol (Oral)matched approximately | Moderate | Antagonism | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol… | 4 sources — open the full entry |
| Chloramphenicol + Lidocaine Hydrochloridematched approximately | Moderate | Antagonism | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol… | 4 sources — open the full entry |
| Cyproterone Acetate + Ethinyl Estradiolmatched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Dexamethasone + Chloramphenicolmatched approximately | Moderate | Antagonism | Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol… | 4 sources — open the full entry |
| Dienogest + Estradiol Valeratematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Doxycycline Hydrochloridematched approximately | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Drospirenone + Estradiolmatched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol0.02 mg0.03 mgmatched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Drospirenone + Ethinyl Estradiol + Levomefolatematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Entecavir Monohydratematched approximately | Moderate | Excretion | Coadministration of entecavir with another drug that is also eliminated by active tubular secretion may result in increased plasma concentrations of one or… | 2 sources — open the full entry |
| Estradiolbasevaginal creammatched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol + Dydrogesteronematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Hemihydrate + Progesterone Micronizedmatched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Estradiol Valeratematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Desogestrel0.02 mg0.03 mgmatched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Gestodenematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Levonorgestrel + Ferrous Fumaratematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Ethinyl Estradiol + Lynestrenol0.0375 mg0.05 mgmatched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Minocycline Hydrochloridematched approximately | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Mycophenolate Mofetilmatched approximately | Moderate | Absorption | Theoretically, drugs that alter the gastrointestinal flora (e.g., antibiotics) may reduce the oral bioavailability of mycophenolic acid products. Some… | 3 sources — open the full entry |
| Mycophenolic acidmatched approximately | Moderate | Absorption | Theoretically, drugs that alter the gastrointestinal flora (e.g., antibiotics) may reduce the oral bioavailability of mycophenolic acid products. Some… | 3 sources — open the full entry |
| Norgestrel + Ethinyl Estradiol + Ferrous Fumaratematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Oxytetracyclinematched approximately | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Oxytetracycline + Polymixin B Sulphatematched approximately | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Pemetrexedmatched approximately | Moderate | Excretion | Coadministration with drugs that are eliminated by active tubular secretion may delay and/or decrease the clearance of pemetrexed. The mechanism is competitive… | 1 sources — open the full entry |
| Relugolix + Estradiol + Norethindronematched approximately | Moderate | Antagonism | RECOMMENDED: The effectiveness of estrogen-containing oral contraceptives may be impaired by concomitant treatment with antimicrobial agents. Most… | 38 sources — open the full entry |
| Tetracycline Hydrochloridematched approximately | Moderate | Antagonism | Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by… | 8 sources — open the full entry |
| Warfarin Sodiummatched approximately | Moderate | Synergy | Penicillins may occasionally potentiate the risk of bleeding in patients treated with oral anticoagulants. The exact mechanism of interaction is unknown but… | 54 sources — open the full entry |
| Azithromycin DihydratebaseOphthalmicmatched approximately | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| Clarithromycinmatched approximately | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| ErythromycinLotionOralmatched approximately | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| Esomeprazole + Amoxicillin + Clarithromycinmatched approximately | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| Lansoprazole + Amoxicillin + Clarithromycinmatched approximately | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| Rabeprazole + Amoxicillin + Clarithromycinmatched approximately | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
| Vonoprazan + Amoxicillin + Clarithromycinmatched approximately | Minor | Others | Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are… | 3 sources — open the full entry |
Conditions
Conditions in which Benzathine Benzylpenicillin needs care, as documented in this source.
Colitis
MajorClostridioides difficile-associated diarrhea (CDAD), formerly pseudomembranous colitis, has been reported with almost all antibacterial drugs and may range from mild diarrhea to fatal colitis. The most common culprits include clindamycin and lincomycin. Antibacterial therapy alters the normal flora of the colon, leading to overgrowth of C difficile, whose toxins A and B contribute to CDAD development. Morbidity and mortality are increased with hypertoxin-producing strains of C difficile; these infections can be resistant to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea after antibacterial use. Since CDAD has been reported to occur more than 2 months after antibacterial use, careful medical history is necessary. Therapy with broad-spectrum antibacterials and other agents with significant antibacterial activity should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis; pseudomembranous colitis (generally characterized by severe, persistent diarrhea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus), if it occurs, may be more severe in these patients and may be associated with flares in underlying disease activity. Antibacterial drugs not directed against C difficile may need to be stopped if CDAD is suspected or confirmed. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation should be started as clinically indicated.
31 sources
- "Product Information. Omnipen (ampicillin)." Wyeth-Ayerst Laboratories (2002):
- "Product Information. Ceftin (cefuroxime)." Glaxo Wellcome (2002):
- "Product Information. Zinacef (cefuroxime)." Glaxo Wellcome (2002):
- "Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn (2002):
- "Product Information. Macrobid (nitrofurantoin)." Procter and Gamble Pharmaceuticals (2002):
- "Product Information. Macrodantin (nitrofurantoin)." Procter and Gamble Pharmaceuticals (2002):
- "Product Information. Amoxil (amoxicillin)." SmithKline Beecham (2001):
- "Product Information. Merrem (meropenem)." Astra-Zeneca Pharmaceuticals (2001):
Show all 31 sourcesShow fewer sources
- "Product Information. Coly-Mycin M Parenteral (colistimethate)." Parke-Davis (2001):
- "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn (2001):
- "Product Information. Cubicin (daptomycin)." Cubist Pharmaceuticals Inc (2003):
- "Product Information. Xifaxan (rifaximin)." Salix Pharmaceuticals (2004):
- "Product Information. Doribax (doripenem)." Ortho McNeil Pharmaceutical (2007):
- "Product Information. Penicillin G Procaine (procaine penicillin)." Monarch Pharmaceuticals Inc (2009):
- "Product Information. Vibativ (telavancin)." Theravance Inc (2009):
- "Product Information. Teflaro (ceftaroline)." Forest Pharmaceuticals (2010):
- "Product Information. Penicillin G Sodium (penicillin G sodium)." Sandoz Inc (2022):
- "Product Information. Dalvance (dalbavancin)." Durata Therapeutics, Inc. (2014):
- "Product Information. Orbactiv (oritavancin)." The Medicines Company (2014):
- "Product Information. Bicillin C-R (benzathine penicillin-procaine penicillin)." A-S Medication Solutions (2017):
- "Product Information. Baxdela (delafloxacin)." Melinta Therapeutics, Inc. (2017):
- "Product Information. Polymyxin B Sulfate (polymyxin B sulfate)." AuroMedics Pharma LLC (2022):
- "Product Information. Zemdri (plazomicin)." Achaogen (2018):
- "Product Information. Seysara (sarecycline)." Allergan Inc (2018):
- "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc. (2018):
- "Product Information. Aemcolo (rifamycin)." Aries Pharmaceuticals, Inc. (2018):
- "Product Information. Fetroja (cefiderocol)." Shionogi USA Inc (2019):
- "Product Information. Biaxin (clarithromycin)." AbbVie US LLC (2019):
- "Product Information. Zithromax (azithromycin)." Pfizer U.S. Pharmaceuticals Group (2021):
- "Product Information. E.E.S.-400 Filmtab (erythromycin)." Arbor Pharmaceuticals (2018):
- "Product Information. Priftin (rifapentine)." sanofi-aventis (2020):
Asthma
ModeratePenicillin products should be used with caution in individuals with histories of significant allergies and/or asthma.
1 source
- "Product Information. Penicillin G Procaine (procaine penicillin)." Monarch Pharmaceuticals Inc (2009):
Therapeutic duplication
Drug classes that overlap with Benzathine Benzylpenicillin, so taking both doubles up the same effect. This source publishes no per-row citations for duplication.
beta-lactam antibiotics
The recommended maximum number of medicines in the 'beta-lactam antibiotics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'beta-lactam antibiotics' category.
Example product in the source data (US market): Prevpac
beta-lactam antibiotics
The recommended maximum number of medicines in the 'beta-lactam antibiotics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'beta-lactam antibiotics' category.
Example product in the source data (US market): Amoxicillin/clarithromycin/omeprazole
beta-lactam antibiotics
The recommended maximum number of medicines in the 'beta-lactam antibiotics' category to be taken concurrently is usually one.Your list includes two medicines belonging to the 'beta-lactam antibiotics' category.
Example product in the source data (US market): Voquezna triple pak