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Amlodipine Besilate + Valsartan + Heparin Sodium

Moderate 13 published sources

This interaction is documented in this data source.

Amlodipine Besilate + Valsartan
Checked as Amlodipine + Valsartan
Heparin Sodium
Checked as Heparin

2 documented mechanisms

This source documents more than one distinct mechanism for this pair. Each is shown with its own effect, advice and sources rather than merged into one.

  1. Mechanism 1: Synergy

    Moderate

    via Valsartan and Heparin

    What happens

    The concomitant use of angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) and heparin or low molecular weight heparins may increase the risk of hyperkalemia. ACE inhibitors, ARBs, and some heparins individually have been associated with increased potassium levels or hyperkalemia.

    What to do

    Caution is advised if ACE inhibitors or ARBs are used with heparin or low molecular weight heparin. Serum potassium and renal function should be checked regularly.

    13 sources

    1. "Product Information. Micardis (telmisartan)." Boehringer-Ingelheim, Ridgefield, CT.
    2. "Product Information. Diovan (valsartan)." Novartis Pharmaceuticals, East Hanover, NJ.
    3. "Product Information. Avapro (irbesartan)." Bristol-Myers Squibb, Princeton, NJ.
    4. "Product Information. Atacand (candesartan)." Astra Pharmaceuticals, Wayne, PA.
    5. "Product Information. Teveten (eprosartan)." SmithKline Beecham, Philadelphia, PA.
    6. "Product Information. Benicar (olmesartan)." Sankyo Parke Davis, Parsippany, NJ.
    7. Perazella MA "Drug-induced hyperkalemia: old culprits and new offenders." Am J Med 109 (2000): 307-14
    8. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
    Show all 13 sources
    1. "Product Information. Cozaar (losartan)." Merck & Co, Inc, West Point, PA.
    2. "Product Information. Edarbi (azilsartan)." Takeda Pharmaceuticals America, Lincolnshire, IL.
    3. Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20
    4. "Product Information. Vasotec (enalapril)." Merck & Co, Inc, West Point, PA.
    5. Good CB, McDermott L "Diet and serum potassium in patients on ACE inhibitors." JAMA 274 (1995): 538

  2. Mechanism 2: Unknown

    Listed, not described

    via Amlodipine and Heparin

    The source lists this pair here and publishes no description, mechanism or citation for it.

    No sources recorded

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