Aluminium Hydroxide + Magnesium Hydroxide + Simethicone + Indapamide + Amlodipine

What is documented

1. Synergy

   Moderate

   via Magnesium hydroxide and Indapamide

   What happens

   The chronic use or abuse of laxatives may potentiate the pharmacologic effects of diuretics. Laxatives can cause significant losses of fluid and electrolytes, including sodium, potassium, magnesium and zinc, and these effects may be additive to those of diuretics.

   What to do

   In general, laxatives should only be used on a short-term, intermittent basis in recommended dosages. During concomitant use with diuretics, patients should be advised to contact their physician if they experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urination, postural hypotension, and tachycardia. If maintenance of bowel regularity is required, patients should be advised to exercise and increase fiber in the diet and/or consider the use of bulk-forming laxatives.

   5 sources

   1. Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45
   2. Blumenthal M, Goldberg A, Brinckmann J, eds. "Herbal Medicine: Expanded Commission E Monographs." Newton, MA: Integrative Medicine Communications (2000):
   3. Atsmon J, Dolev E "Drug-induced hypomagnesaemia : scope and management." Drug Saf 28 (2005): 763-88
   4. Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8
   5. Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61

Keep checking

• Add a third medicine
• Everything for Aluminium Hydroxide + Magnesium Hydroxide + Simethicone
• Everything for Indapamide + Amlodipine