Skip to content
Med Rx.

Aclidinium Bromide + Formoterol Fumarate + Salmeterol Xinafoate

Moderate 11 published sources

This interaction is documented in this data source.

Aclidinium Bromide + Formoterol Fumarate
Checked as Aclidinium + Formoterol
Salmeterol Xinafoate
Checked as Salmeterol

What is documented

  1. Synergy

    Moderate

    via Formoterol and Salmeterol

    What happens

    Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists can produce clinically significant cardiovascular effects including increases in pulse rate and systolic or diastolic blood pressure as well as ECG changes such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. The risk is lower when beta-2 adrenergic agonists are inhaled at normally recommended dosages.

    What to do

    Caution is advised if beta-2 adrenergic agonists are used concomitantly with other adrenergic agents, particularly in patients with cardiovascular disorders such as coronary insufficiency, cardiac arrhythmias, hypertrophic obstructive cardiomyopathy, or hypertension. Blood pressure and heart rate should be closely monitored.

    11 sources

    1. Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51
    2. "Product Information. Brovana (arformoterol)." Sepracor Inc, Marlborough, MA.
    3. "Product Information. Breo Ellipta (fluticasone-vilanterol)." GlaxoSmithKline, Research Triangle Park, NC.
    4. "Product Information. Maxair (pirbuterol)." 3M Pharmaceuticals, St. Paul, MN.
    5. "Product Information. Arcapta Neohaler (indacaterol)." Novartis Pharmaceuticals, East Hanover, NJ.
    6. "Product Information. Proventil (albuterol)." Schering Laboratories, Kenilworth, NJ.
    7. Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9
    8. "Product Information. Foradil (formoterol)" Novartis Pharmaceuticals, East Hanover, NJ.
    Show all 11 sources
    1. "Product Information. Striverdi Respimat (olodaterol)." Boehringer Ingelheim, Ridgefield, CT.
    2. "Product Information. Severent (salmeterol)." Glaxo Wellcome, Research Triangle Park, NC.
    3. "Product Information. Xopenex (levalbuterol)." Sepracor, Marlborough, MA.

Keep checking