Vibegron

Vibegron is indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults.

Vibegron is a potent, selective beta-3 adrenergic receptor agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity.

The recommended dosage of Vibegron is one 75 mg tablet orally, once daily with or without food. Use in Children: Safety and effectiveness of Vibegron in pediatric patients have not been established.

Concomitant use of Vibegron increases digoxin maximal concentrations (Cmax) and systemic exposure as assessed by area under the concentration-time curve (AUC). Serum digoxin concentrations should be monitored before initiating and during therapy with Vibegron and used for titration of the digoxin dose to obtain the desired clinical effect. Continue monitoring digoxin concentrations upon discontinuation of Vibegron and adjust digoxin dose as needed.

Vibegron is contraindicated in patients with known hypersensitivity to Vibegron or any components of the product.

The most common adverse reactions of Vibegron include: Urinary tract infection, nasal congestion, sore throat or runny nose, nausea, headache, diarrhea, upper respiratory tract infection.

There are no available data on Vibegron use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. There are no data on the presence of Vibegron in human milk, the effects of the drug on the breastfed infant, or the effects on milk production.

Urinary retention has been reported in patients taking Vibegron. Discontinue Vibegron in patients who develop urinary retention.

There is no experience with inadvertent Vibegron overdose. In case of suspected overdose, treatment should be symptomatic and supportive.

β₃-adrenergic receptor agonist

Store below 30⁰C in a dry place, protect from light. Keep out of reach of children.